Id proteins synchronize stemness and anchorage to the niche of neural stem cells
| العنوان: | Id proteins synchronize stemness and anchorage to the niche of neural stem cells |
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| المؤلفون: | Antonio Iavarone, Yuan Zhuang, Diego di Bernardo, Xudong Zhao, Mario Lauria, Robert Benezra, Devendra Singh, Anna Lasorella, Ryan J. Sullivan, Francesco Niola, Hyung-song Nam, Angelica Castano |
| المساهمون: | Niola, F, Zhao, X, Singh, D, Castano, A, Sullivan, R, Lauria, M, Nam, H, Zhuang, Y, Benezra, R, DI BERNARDO, Diego, Iavarone, A, Lasorella, A. |
| المصدر: | Nature Cell Biology. 14:477-487 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | GTPase-activating protein, GTPase-Activating Proteins, Niche, Integrin, Regulator, Cell Biology, GTPase, Biology, Neural stem cell, Cell biology, Mice, Neural Stem Cells, Antigens, Neoplasm, Basic Helix-Loop-Helix Transcription Factors, Cell Adhesion, biology.protein, Animals, Rap1, Cell adhesion |
| الوصف: | Stem-cell functions require activation of stem-cell-intrinsic transcriptional programs and extracellular interaction with a niche microenvironment. How the transcriptional machinery controls residency of stem cells in the niche is unknown. Here we show that Id proteins coordinate stem-cell activities with anchorage of neural stem cells (NSCs) to the niche. Conditional inactivation of three Id genes in NSCs triggered detachment of embryonic and postnatal NSCs from the ventricular and vascular niche, respectively. The interrogation of the gene modules directly targeted by Id deletion in NSCs revealed that Id proteins repress bHLH-mediated activation of Rap1GAP, thus serving to maintain the GTPase activity of RAP1, a key mediator of cell adhesion. Preventing the elevation of the Rap1GAP level countered the consequences of Id loss on NSC-niche interaction and stem-cell identity. Thus, by preserving anchorage of NSCs to the extracellular environment, Id activity synchronizes NSC functions to residency in the specialized niche. |
| وصف الملف: | STAMPA |
| تدمد: | 1476-4679 1465-7392 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cea74cb127b1848e6f521cd1136abaTest https://doi.org/10.1038/ncb2490Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c0cea74cb127b1848e6f521cd1136aba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764679 14657392 |
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