Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer
| العنوان: | Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer |
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| المؤلفون: | Simon Gronowitz, Oliver Strobel, Magnus Neumüller, Ulf Hinz, Mattias Bergqvist, Sophie Dobiasch, Klaus Felix, Frank Bergmann, Thilo Hackert |
| المصدر: | Pancreas. 47:72-79 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Oncology, medicine.medical_specialty, Thymidine kinase activity, Pancreatic ductal adenocarcinoma, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Kaplan-Meier Estimate, Thymidine Kinase, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Predictive Value of Tests, Internal medicine, Pancreatic cancer, Outcome Assessment, Health Care, Biomarkers, Tumor, Internal Medicine, medicine, Carcinoma, Humans, Thymidine kinase 1, Neoadjuvant therapy, Aged, Monitoring, Physiologic, Predictive biomarker, Hepatology, business.industry, Middle Aged, Prognosis, medicine.disease, Neoadjuvant Therapy, digestive system diseases, Pancreatic Neoplasms, 030104 developmental biology, 030220 oncology & carcinogenesis, Predictive value of tests, Preoperative Period, business, Carcinoma, Pancreatic Ductal |
| الوصف: | The aim of the study was to investigate serum thymidine kinase 1 (S-TK) activity as a diagnostic and prognostic marker for patients with pancreatic ductal adenocarcinoma (PDAC).Using the sensitive TK activity assay DiviTum, preoperative serum samples from 404 PDAC, 28 chronic pancreatitis, and 25 autoimmune pancreatitis patients and 83 healthy volunteers were analyzed. The preoperative S-TK activities of 54 PDAC patients who received neoadjuvant therapy (nTx) were also compared with those of 258 PDAC patients who did not receive nTx.The preoperative S-TK activities of PDAC patients were significantly higher and discriminatory from autoimmune and chronic pancreatitis patients and control groups. The S-TK activity in PDAC patients was associated with overall survival. Patients with S-TK activity of less than 80 Du (DiviTum units)/L demonstrated median survival of 20.3 months with an estimated 18.0% 5-year survival rate; for S-TK activity of 80 Du/L or greater, median survival was 15.1 months with a 6.8% 5-year survival rate. For early-stage PDAC, these differences were even more pronounced. The S-TK activity in the nTx group was significantly higher than that in the group not receiving nTx.Pancreatic ductal adenocarcinomas reveal a significant increase in S-TK activity, which is associated with overall survival, especially in early tumor stages. Serum thymidine kinase 1 activity may be a useful parameter for monitoring nTx efficacy. |
| تدمد: | 1536-4828 0885-3177 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ac6b9a320cf964e94012753d6e396dTest https://doi.org/10.1097/mpa.0000000000000966Test |
| رقم الانضمام: | edsair.doi.dedup.....c0ac6b9a320cf964e94012753d6e396d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15364828 08853177 |
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