Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children
| العنوان: | Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children |
|---|---|
| المؤلفون: | Alireza Nezami, Fariba Tarhani, Ghobad Heidari |
| المصدر: | Journal of Pediatric Endocrinology and Metabolism. 33:761-765 |
| بيانات النشر: | Walter de Gruyter GmbH, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Comorbidity, Iran, Gastroenterology, Diabetic nephropathy, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, Humans, Medicine, Diabetic Nephropathies, Age of Onset, Renal Insufficiency, Chronic, Child, Klotho Proteins, Klotho, Glucuronidase, business.industry, Type i diabetes mellitus, Infant, Newborn, Infant, Soluble klotho, α klotho, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, 030104 developmental biology, Case-Control Studies, Child, Preschool, Insulin dependent diabetes, Pediatrics, Perinatology and Child Health, Female, business, Biomarkers |
| الوصف: | Objectives Reduced levels of α-Klotho is associated with the pathogenesis of various diseases including diabetes. In type I diabetes, decrease in Klotho leads to apoptosis of β-cells of pancreases. The aim of this study was to evaluate the levels of α-Klotho in type I diabetic pediatric patients. Methods In this cross-sectional single centered study, 46 patients presenting type I diabetes mellitus (case group) and 78 control group under the age of 12, referred to our clinic were included in our study. Serum levels of soluble Klotho were measured by sandwich ELISA in case and control groups. Statistical analysis was conducted for the data recorded via questionnaire. Results Mean age of the patients in the case and control group was 7.65 ± 3.09 and 7 ± 2.37, respectively. Type I diabetes patients had a significant reduction in the levels of serum Klotho, as compared to controls (p Conclusions This study reports a significant decrease in the serum levels of α-Klotho in type 1 diabetic patients. Low levels of Klotho can be associated with diabetic nephropathy and other comorbidities in these patients. |
| تدمد: | 2191-0251 0334-018X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdd7d379a5ae756b2081f8d80cb2a9bTest https://doi.org/10.1515/jpem-2019-0591Test |
| رقم الانضمام: | edsair.doi.dedup.....bfdd7d379a5ae756b2081f8d80cb2a9b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21910251 0334018X |
|---|