Two distinct immunopathological profiles in autopsy lungs of COVID-19
| العنوان: | Two distinct immunopathological profiles in autopsy lungs of COVID-19 |
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| المؤلفون: | Tobias Junt, Gieri Cathomas, Kirsten D. Mertz, Viktor H. Koelzer, Holger Moch, Francesca Demichelis, Thomas Hoyler, Alexandar Tzankov, Nathalie Schwab, Niels Willi, Maurice Henkel, Werner Kempf, Angela Frank, Ronny Nienhold, Thomas Menter, Markus Tolnay, Veronika Zsikla, Mattia Barbareschi, Jasmin D. Haslbauer, Yari Ciani |
| المساهمون: | University of Zurich, Mertz, Kirsten D |
| المصدر: | Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020) Nature Communications |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Pathology, General Physics and Astronomy, Autopsy, CD8-Positive T-Lymphocytes, medicine.disease_cause, Transcriptome, 0302 clinical medicine, Interferon, Sequencing, lcsh:Science, Lung, Coronavirus, Aged, 80 and over, Multidisciplinary, Respiratory disease, virus diseases, Middle Aged, Viral Load, respiratory system, 3100 General Physics and Astronomy, Vaccination, 030220 oncology & carcinogenesis, Cytokines, Female, Infection, Coronavirus Infections, Viral load, medicine.drug, medicine.medical_specialty, Immunopathogenesis, Coronavirus disease 2019 (COVID-19), Science, Pneumonia, Viral, 610 Medicine & health, 1600 General Chemistry, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Betacoronavirus, 03 medical and health sciences, Immune system, 1300 General Biochemistry, Genetics and Molecular Biology, 10049 Institute of Pathology and Molecular Pathology, medicine, Humans, Pandemics, Gene, Aged, SARS-CoV-2, business.industry, Gene Expression Profiling, Macrophages, COVID-19, General Chemistry, medicine.disease, respiratory tract diseases, Pneumonia, 030104 developmental biology, Viral infection, Normal lung, Immunology, lcsh:Q, Interferons, business, CD8 |
| الوصف: | Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles of post mortem COVID-19 (n = 34 tissues from 16 patients) and normal lung tissues (n = 9 tissues from 6 patients). Two distinct immunopathological reaction patterns of lethal COVID-19 are identified. One pattern shows high local expression of interferon stimulated genes (ISGhigh) and cytokines, high viral loads and limited pulmonary damage, the other pattern shows severely damaged lungs, low ISGs (ISGlow), low viral loads and abundant infiltrating activated CD8+ T cells and macrophages. ISGhigh patients die significantly earlier after hospitalization than ISGlow patients. Our study may point to distinct stages of progression of COVID-19 lung disease and highlights the need for peripheral blood biomarkers that inform about patient lung status and guide treatment. The immunopathological features of SARS-CoV-2 infection in the lungs remain unclear. Here, the authors provide a comprehensive characterization of post mortem lung tissues of COVID-19 patients and find two distinct patterns characterized by differential expression of interferon stimulated genes (ISGs), which correlate to viral loads, cytokines, lung damage and time of hospitalization, suggesting ISG profiles to mark disease progression |
| وصف الملف: | 41467_2020_Article_18854.pdf - application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcef5634ca7109b9302c546a8275918Test http://link.springer.com/article/10.1038/s41467-020-18854-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bfcef5634ca7109b9302c546a8275918 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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