Multicentric lymphoma in buffaloes in the Amazon region, Brazil
| العنوان: | Multicentric lymphoma in buffaloes in the Amazon region, Brazil |
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| المؤلفون: | José Diomedes Barbosa, Cairo H.S. de Oliveira, Geovanni Dantas Cassali, Carlos M.G. de Oliveira, Rômulo Cerqueira Leite, Jenner Karlisson Pimenta dos Reis, Karine Araújo Damasceno |
| المصدر: | BMC Veterinary Research, Vol 12, Iss 1, Pp 1-10 (2016) BMC Veterinary Research |
| بيانات النشر: | BMC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Immunodeficiency Virus, Bovine, medicine.medical_specialty, Buffaloes, Lymphoma, 040301 veterinary sciences, animal diseases, BLV, Buffalo, Virus, Leucosis, 0403 veterinary science, 03 medical and health sciences, medicine, Animals, BoHV-6, Cell Proliferation, B-Lymphocytes, BIV, lcsh:Veterinary medicine, General Veterinary, Bovine leukemia virus, biology, business.industry, Bovine immunodeficiency virus, 04 agricultural and veterinary sciences, General Medicine, biology.organism_classification, medicine.disease, veterinary(all), Virology, 030104 developmental biology, lcsh:SF600-1100, Female, Histopathology, Lymph, business, Peripheral lymph, Brazil, Research Article |
| الوصف: | Background The presence of lymphoma in buffaloes was first reported in India in the 1960s. The disease is similar to Enzootic Bovine Leucosis (EBL) caused by Bovine leukemia virus (BLV) in cattle; however, according to our results and those of other studies, the etiology of these lymphomas in buffalo do not appear to be associated with BLV. The objectives of this study are to describe four cases of the disease in buffaloes belonging to the same herd in the Amazon region of Brazil and to perform a clinical-anatomopathological, immunohistochemical, and etiological study of the lymphomas. Results Over a period of ten years, four buffaloes were observed presenting progressive weight loss, swelling of peripheral lymph nodes, and nodules in the subcutaneous tissue. Upon necropsy, whitish-colored tumor masses were observed in the form of nodules in the subcutaneous tissue, along with miliary nodules on the serosal surfaces of abdominal and thoracic organs and tumors in lymph nodes and other organs. Neoplastic lymphocyte proliferation was observed through histopathology. An immunohistochemical study revealed that the neoplasias were formed by proliferation of predominantly B lymphocytes. The presence of BLV genome was not detected in the lymphomas when using the real-time PCR technique, nor was it detected through immunohistochemical staining using monoclonal antibodies against two viral proteins. Bovine herpesvirus 6 was not detected in the tumors. However, Bovine immunodeficiency virus (BIV) was detected in samples of lymphoma and in the lymph nodes and kidneys of one of the animals. Conclusions The occurrence of lymphoma in buffaloes is reported for the first time in Brazil and is characterized by B-cell multicentric lymphoma. The etiology of the disease does not appear to be associated with BLV; however, the detection of BIV in samples of lymphoma from one sick animal deserves further study, considering the oncogenic potential of this virus. Electronic supplementary material The online version of this article (doi:10.1186/s12917-016-0845-y) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 1746-6148 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0148d4ee6851e34a9acb3581fcf7b1Test http://link.springer.com/article/10.1186/s12917-016-0845-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf0148d4ee6851e34a9acb3581fcf7b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17466148 |
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