Objective physical and mental markers of self‐reported fatigue in women undergoing (neo)adjuvant chemotherapy for early‐stage breast cancer
| العنوان: | Objective physical and mental markers of self‐reported fatigue in women undergoing (neo)adjuvant chemotherapy for early‐stage breast cancer |
|---|---|
| المؤلفون: | Joanne E. Mortimer, Arti Hurria, Carolyn E. Behrendt, Sarah Waliany, Joseph Chao, Christina M. Dieli-Conwright, Sunita K. Patel, Brian Tiep |
| المصدر: | Cancer |
| بيانات النشر: | Wiley, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Oncology, Cancer Research, Neuropsychological Tests, chemotherapy, Pittsburgh Sleep Quality Index, cancer‐related fatigue, Grip strength, 0302 clinical medicine, Surveys and Questionnaires, Antineoplastic Combined Chemotherapy Protocols, Medicine, Cancer-related fatigue, Chemokine CCL2, Fatigue, Depression (differential diagnoses), Chemokine CCL3, Depression, Middle Aged, Interleukin-12, Neoadjuvant Therapy, 3. Good health, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Original Article, Female, medicine.symptom, Adult, Chemokine CCL11, medicine.medical_specialty, Breast Neoplasms, Walk Test, Discipline, 03 medical and health sciences, breast cancer, physical function, Breast cancer, Internal medicine, Humans, Clinical Trials, Cyclophosphamide, Neoplasm Staging, Trail Making Test, business.industry, Cancer, Original Articles, medicine.disease, Clinical trial, Interleukin 1 Receptor Antagonist Protein, Doxorubicin, Linear Models, Self Report, Energy Metabolism, Sleep, business, Neurocognitive, 030217 neurology & neurosurgery |
| الوصف: | BACKGROUND Objective, treatment‐independent markers of cancer‐related fatigue are needed to advance clinical trials. In the current study, the authors evaluated physical, neurocognitive, and serologic markers for correlation with self‐reported fatigue before and after (neo)adjuvant chemotherapy for patients with early‐stage breast cancer. METHODS Women with AJCC TNM Stage I‐III breast cancer consented to assessment before and after the completion of 4 cycles of dose‐dense doxorubicin and cyclophosphamide. Assessment included self‐reported fatigue (using the Brief Fatigue Inventory), depression (using the Center for Epidemiologic Studies–Depression Scale [CES‐D]), Pittsburgh Sleep Quality Index, and 28 objective measures (grip strength in dominant and nondominant hands, 6‐minute walk, daily total energy expenditure, 14 neurocognitive tests, and 10 serologic markers). Generalized linear regression models of fatigue were constructed (1 model per marker), and adjusted for depression, timing before/after chemotherapy, menopausal status, obesity, and educational level. P values were adjusted to control the False Discovery Rate. RESULTS Of 28 subjects, 3 withdrew without completing baseline assessments. Prechemotherapy and postchemotherapy data were available for the evaluation of physical measures (25 subjects aged 50.6 ± 9.5 years), neurocognitive tests (22 subjects), and serologic markers (10 subjects). On covariate‐adjusted analysis, interleukin (IL)‐12 was found to be associated with fatigue at both assessments (P To identify objective measures of cancer‐related fatigue, herein the authors evaluate physical, neurocognitive, and serologic markers for correlation with the Brief Fatigue Inventory before and after (neo)adjuvant chemotherapy for patients with early‐stage breast cancer. Although several markers correlate with self‐reported fatigue at one assessment, only the cytokine interleukin 12 appears to correlate with fatigue both before and after chemotherapy. |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea658d2ccb9966856d7ae52230a0b12Test https://doi.org/10.1002/cncr.30426Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bea658d2ccb9966856d7ae52230a0b12 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
|---|