Muscarinic receptors and ligands in cancer
| العنوان: | Muscarinic receptors and ligands in cancer |
|---|---|
| المؤلفون: | Jean-Pierre Raufman, Kunrong Cheng, Sandeep Khurana, Nirish Shah |
| المصدر: | American Journal of Physiology-Cell Physiology. 296:C221-C232 |
| بيانات النشر: | American Physiological Society, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Protein Conformation, Physiology, Antineoplastic Agents, Apoptosis, Review, Muscarinic Antagonists, Biology, Ligands, Paracrine signalling, Cell Movement, Neoplasms, Muscarinic acetylcholine receptor, medicine, Animals, Humans, Receptor, Autocrine signalling, Cell Proliferation, Acetylcholine receptor, Neurons, Cancer, Cell Biology, medicine.disease, Receptors, Muscarinic, Acetylcholine, Cell biology, Immunology, Disease Progression, Signal transduction, Signal Transduction, medicine.drug |
| الوصف: | Emerging evidence indicates that muscarinic receptors and ligands play key roles in regulating cellular proliferation and cancer progression. Both neuronal and nonneuronal acetylcholine production results in neurocrine, paracrine, and autocrine promotion of cell proliferation, apoptosis, migration, and other features critical for cancer cell survival and spread. The present review comprises a focused critical analysis of evidence supporting the role of muscarinic receptors and ligands in cancer. Criteria are proposed to validate the biological importance of muscarinic receptor expression, activation, and postreceptor signaling. Likewise, criteria are proposed to validate the role of nonneuronal acetylcholine production in cancer. Dissecting cellular mechanisms necessary for muscarinic receptor activation as well as those needed for acetylcholine production and release will identify multiple novel targets for cancer therapy. |
| تدمد: | 1522-1563 0363-6143 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3a24ef994712403dad4eb03a91d16dTest https://doi.org/10.1152/ajpcell.00514.2008Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....be3a24ef994712403dad4eb03a91d16d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221563 03636143 |
|---|