Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity
| العنوان: | Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity |
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| المؤلفون: | Gemma Villuendas, Marta Corton, José Sancho, José L. San Millán, Héctor F. Escobar-Morreale, Belén Peral |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Receptors, Cytoplasmic and Nuclear, Type 2 diabetes, Biochemistry, Receptor, IGF Type 2, Receptor, IGF Type 1, Endocrinology, Risk Factors, Plasma cell differentiation, Insulin-Like Growth Factor I, Pyrophosphatases, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Microfilament Proteins, Middle Aged, Polycystic ovary, female genital diseases and pregnancy complications, Intercellular Signaling Peptides and Proteins, Female, Adiponectin, Polycystic Ovary Syndrome, Adult, medicine.medical_specialty, Adolescent, Genotype, Biology, Insulin resistance, Insulin-Like Growth Factor II, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Diabetes Mellitus, Humans, Genetic Predisposition to Disease, Obesity, Aryldialkylphosphatase, Phosphoric Diester Hydrolases, Insulin, Biochemistry (medical), Paraoxonase, Type 2 Diabetes Mellitus, Proteins, medicine.disease, Diabetes Mellitus, Type 2, biology.protein, Insulin Resistance, Protein Tyrosine Phosphatases, Transcription Factors |
| الوصف: | 7 pages, 2 tables.-- Results from this work were presented at the 85th Annual Meeting of The Endocrine Society, Philadelphia, PA, June 2003. We have evaluated the possible association of polycystic ovary syndrome (PCOS) with 15 genomic variants previously described to influence insulin resistance, obesity, and/or type 2 diabetes mellitus. Seventy-two PCOS patients and 42 healthy controls were genotyped for 15 variants in the genes encoding for paraoxonase (three variants), plasma cell differentiation antigen glycoprotein, human sorbin and SH3 domain containing 1, plasminogen activator inhibitor-1, peroxisome proliferator-activated receptor-gamma2, protein tyrosine phosphatase 1B (two variants), adiponectin (two variants), IGF1, IGF2, IGF1 receptor, and IGF2 receptor. Compared with controls, PCOS patients were more frequently homozygous for the -108T variant in paraoxonase (36.6% vs. 9.5%; P = 0.002) and homozygous for G alleles of the ApaI variant in IGF2 (62.9% vs. 38.1%; P = 0.018). Paraoxonase is a serum antioxidant enzyme and, because -108T alleles result in decreased paraoxonase expression, this increase in oxidative stress might result in insulin resistance. G alleles of the ApaI variant in IGF2 may increase IGF2 expression, and IGF2 stimulates adrenal and ovarian androgen secretion. In conclusion, the paraoxonase -108 C-->T variant and the ApaI polymorphism in the IGF2 gene are associated with PCOS and might contribute to increased oxidative stress, insulin resistance, and hyperandrogenism in this prevalent disorder. This work was supported by grants from the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Spain (FIS 00/0414, 02/0741, and 02/0578 and RGDM G03/212) and from the Consejería de Educación, Comunidad de Madrid, Spain (CAM 08.6/0024/2000 and 08.6/0010/2001). |
| وصف الملف: | 109780 bytes; application/pdf |
| تدمد: | 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be25a69e32008574d12ea058b30a526aTest https://pubmed.ncbi.nlm.nih.gov/15181035Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....be25a69e32008574d12ea058b30a526a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0021972X |
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