Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men
| العنوان: | Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men |
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| المؤلفون: | Alfonso Siani, David A. Tregouet, Marco Versiero, Pasquale Strazzullo, M. Loguercio, Gianvincenzo Barba, Francesco P. Cappuccio, Fabio Lauria, Paola Russo |
| المساهمون: | Génétique épidémiologique et moléculaire des pathologies cardiovasculaires, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-Institut National de la Santé et de la Recherche Médicale (INSERM), Unit of Epidemiology & Population Genetics, Institute of Food Sciences, Department of Clinical and Experimental Medicine, 'Federico II' University of Naples Medical School, Clinical Science Research Institute, Warwick Medical School, University of Warwick [Coventry]-University of Warwick [Coventry], The OPHS was supported in part by MIUR (Italian Ministry of University and Research, COFIN 2004 and FIRB 2001). The WHSS has received support from the Wandsworth Health Authority, the South West Thames Regional Health Authority, the NHS R&D Directorate, the British Heart Foundation, the British Diabetic Association, and The Stroke Association., Simon, Marie Francoise, Russo, P, Strazzullo, Pasquale, Cappuccio, Fp, Tregouet, Da, Lauria, F, Loguercio, M, Barba, G, Versiero, Marco, Siani, A. |
| المصدر: | Journal of Clinical Endocrinology and Metabolism Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2007, 92 (6), pp.2382-6. ⟨10.1210/jc.2006-2523⟩ The Journal of clinical endocrinology and metabolism 92 (2007): 2382–2386. doi:10.1210/jc.2006-2523 info:cnr-pdr/source/autori:Russo P; Strazzullo P; Cappuccio FP; Tregouet DA; Lauria F; Loguercio M; Barba G; Versiero M; Siani A./titolo:Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men./doi:10.1210%2Fjc.2006-2523/rivista:The Journal of clinical endocrinology and metabolism/anno:2007/pagina_da:2382/pagina_a:2386/intervallo_pagine:2382–2386/volume:92 Journal of Clinical Endocrinology and Metabolism, 2007, 92 (6), pp.2382-6. ⟨10.1210/jc.2006-2523⟩ |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, MESH: Receptor, Cannabinoid, CB1, Biochemistry, MESH: Genotype, 0302 clinical medicine, Endocrinology, Rimonabant, Gene Frequency, Receptor, Cannabinoid, CB1, Polymorphism (computer science), MESH: Risk Factors, Risk Factors, MESH: Obesity, Body Fat Distribution, MESH: Genetic Variation, 2. Zero hunger, MESH: Aged, 0303 health sciences, MESH: Middle Aged, MESH: Polymorphism, Single Nucleotide, MESH: Genetic Predisposition to Disease, MESH: European Continental Ancestry Group, Middle Aged, Endocannabinoid system, 3. Good health, Phenotype, medicine.drug, medicine.medical_specialty, Genotype, 030209 endocrinology & metabolism, Context (language use), Single-nucleotide polymorphism, Biology, MESH: Phenotype, Polymorphism, Single Nucleotide, White People, 03 medical and health sciences, Internal medicine, medicine, MESH: Gene Frequency, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Body Fat Distribution, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Genetic Predisposition to Disease, Obesity, 030304 developmental biology, Aged, Retrospective Studies, MESH: Humans, Biochemistry (medical), Genetic Variation, MESH: Retrospective Studies, Anthropometry, medicine.disease, MESH: Male, Cannabinoid |
| الوصف: | Context: The endocannabinoid system modulates food intake and body weight in animal models. Treatment with the cannabinoid type 1 receptor blocker, rimonabant, reduces body weight in obese individuals. Objective: The aim of this study was to determine whether single nucleotide polymorphisms of the gene encoding cannabinoid type 1 receptor, CNR1, are associated with body fat mass and distribution in two independent samples of white European adult men. Design, Setting, and Participants: The 3813A/G and 4895A/G single nucleotide polymorphisms at the exon 4 of CNR1 were genotyped in 930 participants to the Olivetti Prospective Heart Study (OPHS) in Southern Italy and in 216 participants to the Wandsworth Heart and Stroke Study in the United Kingdom. Retrospective analysis was also performed on an OPHS subsample (n = 360) for which anthropometric data from 1987 and 1994–1995 examinations were available. Main Outcome Measures: CNR1 genotypes and anthropometric measures of body fat distribution were determined. Results: In the OPHS study, the 3813G allele was associated with increased subscapular skinfold thickness (24.2 ± 9.1 vs. 22.8 ± 7.7 mm; P = 0.031) and waist circumference (WC) (99.1 ± 8.8 vs. 97.7 ± 8.8 cm; P = 0.050). No association was observed with 4895A/G variant. Haplotype analysis confirmed that the unique haplotype carrying the 3813G was associated with increased WC and subscapular skinfold thickness. Similar results were observed in the OPHS retrospective subsample and the Wandsworth Heart and Stroke Study sample. In the latter, the 3813G was associated with increased WC (96.8 ± 11.3 vs. 91.6 ± 10.4 cm; P = 0.006). Conclusions: Genetic variants at CNR1 are associated with obesity-related phenotypes in men. The detection of polymorphic variants in genes involved in the process of fat accumulation may help identify specific targets for pharmacological treatment of obesity and related metabolic abnormalities. |
| وصف الملف: | application/pdf; STAMPA |
| تدمد: | 0021-972X 1945-7197 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd50f1ed2f00413ba9e927635bda8086Test https://pubmed.ncbi.nlm.nih.gov/17405839Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd50f1ed2f00413ba9e927635bda8086 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0021972X 19457197 |
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