Intermittent microalbuminuria in children with type 1 diabetes mellitus without clinical evidence of nephropathy
| العنوان: | Intermittent microalbuminuria in children with type 1 diabetes mellitus without clinical evidence of nephropathy |
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| المؤلفون: | Primus E. Mullis, K. Zuppinger, H. P. Köchli, H. P. Schwarz |
| المصدر: | European Journal of Pediatrics. 147:385-388 |
| بيانات النشر: | Springer Science and Business Media LLC, 1988. |
| سنة النشر: | 1988 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Urology, Renal function, Diabetic nephropathy, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, medicine, Albuminuria, Humans, Diabetic Nephropathies, Child, Glycated Hemoglobin, Creatinine, Proteinuria, business.industry, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, chemistry, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Microalbuminuria, medicine.symptom, beta 2-Microglobulin, business, Kidney disease |
| الوصف: | Microalbuminura (MA) was determined in 127 children and adolescents (age 3-21 years) with type 1 (insulin-dependent) diabetes mellitus. Patients with clinical evidence of long-term complications or macroproteinuria were excluded. Urinary albumin excretion was measured in a nocturnal 12-h collection and correlated with the albumin/creatinine ratio of a urine sample freshly voided on the morning immediately following the collection. The patients were divided into group A (n = 83, age less than 16 years, duration of diabetes 1-13 years, mean 4.4) and group B (n = 44, age greater than 16 years, duration of diabetes 1-19 years, mean 8.7) and compared with appropriate controls. MA above 15 micrograms/min was present in 11 of 83 (13.3%) patients in group A and in 7 of 44 (15.9%) in group B. In a repeat urine collection at least 3 months later elevated MA persisted in 1 of 11 (group A) and in 4 of 7 (group B) patients. There was no correlation between increased MA in a 12-h urine collection and the albumin/creatinine ratio in a subsequently voided urine sample. MA was not strictly dependent on age, sex, duration of diabetes, haemoglobin A1, mean arterial blood pressure, plasma creatinine, creatinine clearance or serum beta-2-microglobulin. Further systematic studies and careful follow up are necessary to appraise whether intermittent MA is indeed an early manifestation of incipient kidney disease in children with type 1 diabetes. |
| تدمد: | 1432-1076 0340-6199 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdf8540708820627c3e5a4a2cfc7900Test https://doi.org/10.1007/bf00496416Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....bcdf8540708820627c3e5a4a2cfc7900 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321076 03406199 |
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