Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
| العنوان: | Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle |
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| المؤلفون: | Hye Ji J. Kim, Samuel A. Dickie, Robert B. Laprairie |
| المصدر: | Psychopharmacology. 240:15-25 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Pharmacology, Orexins, Estradiol, Orexin Receptors, Animals, Female, Estrous Cycle, Peptides, Progesterone |
| الوصف: | Rationale The female menstrual or estrous cycle and its associated fluctuations in circulating estradiol (E2), progesterone, and other gonadal hormones alter orexin or hypocretin peptide production and receptor activity. Depending on the estrous cycle phase, the transcription of prepro-orexin mRNA, post-translational modification of orexin peptide, and abundance of orexin receptors change in a brain region-specific manner. The most dramatic changes occur in the hypothalamus, which is considered the starting point of the hypothalamic-pituitary–gonadal axis as well as the hub of orexin-producing neurons. Thus, hypothalamus-regulated behaviors, including arousal, feeding, reward processing, and the stress response depend on coordinated efforts between E2, progesterone, and the orexin system. Given the rise of orexin therapeutics for various neuropsychiatric conditions including insomnia and affective disorders, it is important to delineate the behavioral outcomes of this drug class in both sexes, as well as within different time points of the female reproductive cycle. Objectives Summarize how the menstrual or estrous cycle affects orexin system functionality in animal models in order to predict how orexin pharmacotherapies exert varying degrees of behavioral effects across the dynamic hormonal milieu. |
| تدمد: | 1432-2072 0033-3158 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc65aac9c825002990632265f8857e3Test https://doi.org/10.1007/s00213-022-06296-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bcc65aac9c825002990632265f8857e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322072 00333158 |
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