Multi-omics approach to precision medicine for immune-mediated diseases
| العنوان: | Multi-omics approach to precision medicine for immune-mediated diseases |
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| المؤلفون: | Keishi Fujio, Mineto Ota |
| المصدر: | Inflammation and Regeneration, Vol 41, Iss 1, Pp 1-6 (2021) Inflammation and Regeneration |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Computer science, Immunology, Computational biology, Review, Expression quantitative trait loci, Genome, 03 medical and health sciences, Annotation, Multi-omics analysis, 0302 clinical medicine, Polygenic risk score, Pathology, Immunology and Allergy, RB1-214, 030203 arthritis & rheumatology, Immune-mediated disease, Epigenome, Precision medicine, Omics, 030104 developmental biology, Disease risk, Multi omics, Transcriptome |
| الوصف: | Recent innovation in high-throughput sequencing technologies has drastically empowered the scientific research. Consequently, now, it is possible to capture comprehensive profiles of samples at multiple levels including genome, epigenome, and transcriptome at a time. Applying these kinds of rich information to clinical settings is of great social significance. For some traits such as cardiovascular diseases, attempts to apply omics datasets in clinical practice for the prediction of the disease risk have already shown promising results, although still under way for immune-mediated diseases. Multiple studies have tried to predict treatment response in immune-mediated diseases using genomic, transcriptomic, or clinical information, showing various possible indicators. For better prediction of treatment response or disease outcome in immune-mediated diseases, combining multi-layer information together may increase the power. In addition, in order to efficiently pick up meaningful information from the massive data, high-quality annotation of genomic functions is also crucial. In this review, we discuss the achievement so far and the future direction of multi-omics approach to immune-mediated diseases. |
| اللغة: | English |
| تدمد: | 1880-8190 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc133e1c88aa3b5546eece07b3066552Test https://doaj.org/article/b1b5e2c8c82541dabb19597fff661d25Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bc133e1c88aa3b5546eece07b3066552 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18808190 |
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