miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3
| العنوان: | miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3 |
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| المؤلفون: | Ming Yang, Yadong Zhang, Xiaoli Chen, Xia Tian, Yiyuan Wan, Jinrong He, Xueting Cheng, Hesheng Luo, Bo Peng, Xiaodong Huang, Yu Ding, Ting Zhan |
| المصدر: | Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 432-442 (2020) Molecular Therapy Oncolytics |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, proliferation, pancreatic cancer, Biology, lcsh:RC254-282, Article, 03 medical and health sciences, 0302 clinical medicine, Pancreatic cancer, medicine, Pharmacology (medical), KLF3, Cell growth, apoptosis, High cell, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, Oncology, Cell culture, Apoptosis, Pancreatic cancer cell, 030220 oncology & carcinogenesis, Cancer research, miR-324-5p, Molecular Medicine |
| الوصف: | Pancreatic cancer cells are characterized by high cell proliferation and low cell apoptosis, but the factors involved in these processes remain to be further studied. In this study, we report that miR-324-5p regulates the proliferation and apoptosis of pancreatic cancer cells through regulating the expression of Krüppel-like factor 3 (KLF3). In both pancreatic cancer tissues and cell lines, the levels of miR-324-5p are significantly increased. Inhibition of miR-324-5p represses cell proliferation but promotes cell apoptosis, whereas overexpression of miR-324-5p exerts the opposite effect. Furthermore, we identified KLF3, a factor regulating pancreatic cancer cell proliferation and apoptosis, as a new direct downstream target of miR-324-5p. Our results suggest that miR-324-5p plays an important role in pancreatic cancer cell proliferation and apoptosis via downregulating the expression of KLF3. Graphical Abstract Pancreatic cancer cells are characterized by high cell proliferation and low cell apoptosis, but the factors involved in these processes remain to be further studied. In this study, Zhang and colleagues report that miR-324-5p plays an important role in pancreatic cancer cell proliferation and apoptosis through downregulating the expression of KLF3. |
| تدمد: | 2372-7705 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd54e717a36b6d6d3234f6f5e6b7149Test https://doi.org/10.1016/j.omto.2020.07.011Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bbd54e717a36b6d6d3234f6f5e6b7149 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23727705 |
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