Mechanics of PAK1—A new molecular player in the arena of skin cancer
| العنوان: | Mechanics of PAK1—A new molecular player in the arena of skin cancer |
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| المؤلفون: | Swarnalatha Beesetti, Ganesh Venkatraman, R P Surabhi, Suresh K. Rayala |
| المصدر: | Journal of Cellular Physiology. 234:969-975 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Keratinocytes, 0301 basic medicine, Skin Neoplasms, DNA Repair, Ultraviolet Rays, Physiology, Clinical Biochemistry, Pyrimidine dimer, Ataxia Telangiectasia Mutated Proteins, 03 medical and health sciences, 0302 clinical medicine, PAK1, Biomarkers, Tumor, medicine, Humans, Epidermal growth factor receptor, Complete response, Skin, integumentary system, biology, Kinase, Chemistry, Cell Biology, medicine.disease, ErbB Receptors, 030104 developmental biology, p21-Activated Kinases, Pyrimidine Dimers, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Sun exposure, Skin cancer, Skin lesion, Precancerous Conditions, DNA Damage, Signal Transduction |
| الوصف: | Despite regular exposure of skin to solar UV-B irradiation, most individuals enjoy cancer-free existence, which is a testimony of the inherent capacity of human keratinocytes to either repair or restore cells damged by UV exposure. In this manuscript, we focus on delineating the mechanistic role of p21 activated kinase (Pak1) in UV-B provoked skin lesions. Molecular mechanistic studies revealed that Pak1 is triggered as a consequence to UV-B exposure via epidermal growth factor receptor (EGFR) and cyclobutane pyrimidine dimers (CPD) pathways, and both these membranous (EGFR) and nuclear (CPDs) events converge at Pak1 activation and contribute in a coordinated manner for yielding a complete response to UV-B via upregulating Ataxia-Telangiectasia and Rad3 related (ATR). This is the first study that evaluates the mechanistic role of a signaling molecule, Pak1, in premalignant skin lesions caused by sun exposure and designate that expression and instigation of Pak1 could operate as an alarming indicator of succession towards aggressive form of skin cancer, if neglected. |
| تدمد: | 1097-4652 0021-9541 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9ab506b39c9ef096a5503ea2518689Test https://doi.org/10.1002/jcp.26925Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....bb9ab506b39c9ef096a5503ea2518689 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974652 00219541 |
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