ASXL1 mutations in myeloid neoplasms: pathogenetic considerations, impact on clinical outcomes and survival
| العنوان: | ASXL1 mutations in myeloid neoplasms: pathogenetic considerations, impact on clinical outcomes and survival |
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| المؤلفون: | Juliana Alvarez Argote, Constantin A Dasanu |
| المصدر: | Current Medical Research and Opinion. 34:757-763 |
| بيانات النشر: | Informa UK Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Oncology, medicine.medical_specialty, Myeloid, Nonsense mutation, Chronic myelomonocytic leukemia, Frameshift mutation, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Missense mutation, Clinical significance, Aged, business.industry, Myelodysplastic syndromes, Myeloid leukemia, General Medicine, Middle Aged, medicine.disease, Repressor Proteins, medicine.anatomical_structure, Leukemia, Myeloid, Myelodysplastic Syndromes, 030220 oncology & carcinogenesis, Mutation, Cancer research, Female, business, 030215 immunology |
| الوصف: | ASXL1 gene mutations include nonsense, missense, and frameshift mutations. Although their clinical significance is still debated, they may play an important role in the pathogenesis of several hematologic malignancies.Herein, we offer a comprehensive review on ASXL1 mutations, and link them with survival and clinical outcomes in patients with various myeloid neoplasms. Most relevant publications were identified through searching the PubMed/Medline database for articles published from inception to February 2016.In acute myeloid leukemia (AML), ASXL1 mutations tend to correlate with older age and male gender, and affect predominantly patients with secondary AML. De novo AML patients with ASXL1 mutations had significantly lower complete remission rates after standard high-dose chemotherapy and shorter survival. In chronic myelomonocytic leukemia and low- or intermediate-risk myelodysplastic syndromes, frameshift and nonsense mutations correlated with shorter survival and a higher risk of leukemic transformation. Overall survival was also shorter in primary myelofibrosis in the presence of ASXL1 mutations.Further research on the role of ASXL1 mutations and therapeutic implications in neoplastic myeloid disorders is stringently needed. Given the relatively high prevalence of ASXL1 mutations, larger studies involving patients affected by these mutations will be feasible in the near future. |
| تدمد: | 1473-4877 0300-7995 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badab17843309f305ffbfbb4f17f2f88Test https://doi.org/10.1080/03007995.2016.1276896Test |
| رقم الانضمام: | edsair.doi.dedup.....badab17843309f305ffbfbb4f17f2f88 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14734877 03007995 |
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