Post-injury tendon mechanics are not affected by tamoxifen treatment
| العنوان: | Post-injury tendon mechanics are not affected by tamoxifen treatment |
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| المؤلفون: | Zakary M, Beach, Ashley K, Fung, Stephanie N, Weiss, Louis J, Soslowsky |
| المصدر: | Connective Tissue Research. 64:75-81 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Rheumatology, Orthopedics and Sports Medicine, Cell Biology, Molecular Biology, Biochemistry |
| الوصف: | A growing interest in the mechanisms that govern tendon healing has resulted in the develop-ment of tools, such as the tamoxifen-inducible mouse knockdown model, to address these questions. However, tamoxifen is a selective estrogen receptor modulator and may interfere with the tendon healing process. The objective of this study was to evaluate the effects of tamoxifen on post-injury tendon mechanics in wild-type mice.The mice underwent treatment at the time of injury using an established mouse injury model and the injured tendons were evaluated 3 weeks post-injury. The treatment contained tamoxifen suspended in corn oil and was compared to a treatment with only corn oil, as well as mice with no treatment. Tendons were evaluated by measuring the quasi-static and viscoelastic mechanics, collagen fiber realignment, cellularity, and nuclear morphology.Mechanical testing of the tendons post-injury revealed no changes to viscoelastic mechanics, quasi-static mechanics, or collagen realignment during loading after tamoxifen treatment with the dosage regimen utilized (three daily injections of 4.5 mg/40 g body weight). Additionally, histological analysis revealed no changes to cellularity or cell nuclear shape.Overall, this study revealed that tamoxifen treatment at the time of tendon injury did not result in changes to tendon mechanics or the histological parameters at 3 weeks post-injury. |
| تدمد: | 1607-8438 0300-8207 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac3bbfceb6a0822fbc9758b9104a196Test https://doi.org/10.1080/03008207.2022.2097907Test |
| رقم الانضمام: | edsair.doi.dedup.....bac3bbfceb6a0822fbc9758b9104a196 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16078438 03008207 |
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