Protein-calorie malnutrition, macronutrient supplements, and tuberculosis
| العنوان: | Protein-calorie malnutrition, macronutrient supplements, and tuberculosis |
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| المؤلفون: | von Reyn Cf, Koethe |
| المصدر: | The International Journal of Tuberculosis and Lung Disease. 20:857-863 |
| بيانات النشر: | International Union Against Tuberculosis and Lung Disease, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, 030106 microbiology, Antitubercular Agents, Nutritional Status, Disease, Weight Gain, Protein-Energy Malnutrition, Body Mass Index, 03 medical and health sciences, Recurrence, Risk Factors, Internal medicine, medicine, Humans, Risk factor, Adverse effect, business.industry, Remission Induction, medicine.disease, Clinical trial, Malnutrition, Treatment Outcome, Infectious Diseases, Dietary Supplements, medicine.symptom, business, Body mass index, Weight gain |
| الوصف: | BACKGROUND Protein-calorie malnutrition (PCM) is a risk factor for tuberculosis (TB) disease and may affect treatment outcomes. There is currently no recommended macronutrient intervention for improving the outcome of anti-tuberculosis treatment. METHODS We reviewed current literature on PCM and low body mass index (BMI) as risk factors for tuberculous infection and TB disease, and their effects on anti-tuberculosis treatment. We summarize clinical trials of macronutrient supplementation in the treatment of TB. RESULTS PCM is a well-established risk factor for TB disease; however, data on malnutrition and the risk of tuberculous infection are limited. Malnutrition is associated with an increased risk of mortality and relapse of active TB. Clinical trials of macronutrient supplementation during treatment confirm a 2-3 kg improvement in weight gain at 2 months, and may result in improvement in physical function, sputum conversion and treatment completion, but they have not been powered to assess effects on mortality or relapse. CONCLUSION Assessment of dietary intake, food security, and baseline BMI should be standard practice in anti-tuberculosis treatment, along with dietary counselling. As macronutrient supplementation may have modest benefits and is not associated with adverse events, patients with BMI values |
| تدمد: | 1815-7920 1027-3719 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba997677c30496f837fef02ce7e63611Test https://doi.org/10.5588/ijtld.15.0936Test |
| رقم الانضمام: | edsair.doi.dedup.....ba997677c30496f837fef02ce7e63611 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18157920 10273719 |
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