Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes
| العنوان: | Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes |
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| المؤلفون: | George Dragicevic, Sarah X. Zhang, Kevin D. Croft, J.-X. Ma, Alicia J. Jenkins, David N O'Neal, Connie S Karschimkus, Kevin G. Rowley, Andrzej S. Januszewski, James D. Best, Jasmine S Chung, Trevor A. Mori, Craig Nelson, Timothy J. Lyons, C. A. Harper |
| المصدر: | Diabetic Medicine. 24:1345-1351 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Renal function, Enzyme-Linked Immunosorbent Assay, Body Mass Index, chemistry.chemical_compound, Endocrinology, PEDF, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Protease Inhibitors, Nerve Growth Factors, Eye Proteins, Blood urea nitrogen, Serpins, Glycated Hemoglobin, Creatinine, Diabetic Retinopathy, biology, business.industry, C-reactive protein, Middle Aged, medicine.disease, Oxidative Stress, C-Reactive Protein, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Blood pressure, chemistry, Cystatin C, biology.protein, Female, business, Biomarkers |
| الوصف: | To determine in Type 1 diabetes patients if levels of pigment epithelium-derived factor (PEDF), an anti-angiogenic, anti-inflammatory and antioxidant factor, are increased in individuals with complications and positively related to vascular and renal dysfunction, body mass index, glycated haemoglobin, lipids, inflammation and oxidative stress.Serum PEDF levels were measured by ELISA in a cross-sectional study of 123 Type 1 diabetic patients (71 without and 52 with microvascular complications) and 31 non-diabetic control subjects. PEDF associations with complication status, pulse-wave analysis and biochemical results were explored.PEDF levels [geometric mean (95% CI)] were increased in patients with complications 8.2 (7.0-9.6) microg/ml, vs. complication-free patients [5.3 (4.7-6.0) microg/ml, P0.001] and control subjects [5.3 (4.6-6.1) microg/ml, P0.001; anova between three groups, P0.001], but did not differ significantly between control subjects and complication-free patients (P0.05). In diabetes, PEDF levels correlated (all P0.001) with systolic blood pressure (r = 0.317), pulse pressure (r = 0.337), small artery elasticity (r = -0.269), glycated haemoglobin (r = 0.245), body mass index (r = 0.362), renal dysfunction [including serum creatinine (r = 0.491), cystatin C (r = 0.500)], triglycerides (r = 0.367), and inflammation [including log(e)C-reactive protein (CRP; r = 0.329), and soluble vascular cell adhesion molecule-1 (r = 0.363)]. Age, blood urea nitrogen, systolic blood pressure, pulse pressure and log(e)CRP correlated with PEDF levels in control subjects (all P0.04). PEDF levels were not significantly correlated with measures of oxidative stress: isoprostanes, oxidized low-density lipoprotein or paraoxonase-1 activity. On stepwise linear regression analysis (all subjects), independent determinants of PEDF levels were renal function, triglycerides, inflammation, small artery elasticity and age (r(2) = 0.427).In Type 1 diabetes, serum PEDF levels are associated with microvascular complications, poor vascular health, hyperglycaemia, adiposity and inflammation. |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba314c5d495e57ff8e6e80e482356e87Test https://doi.org/10.1111/j.1464-5491.2007.02281.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ba314c5d495e57ff8e6e80e482356e87 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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