Scrub typhus in patients with acute febrile illness: a 5-year study from India
| العنوان: | Scrub typhus in patients with acute febrile illness: a 5-year study from India |
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| المؤلفون: | Rama Chaudhry, Aparajit Ballav Dey, Sushil K. Kabra, Rakesh Lodha, Naveet Wig, Chandan Kumar Thakur, Bimal Kumar Das, M. S. Chhabra, Nitin Gupta, Vishwajeet Singh, E V Vinayaraj, R S Jadon |
| المصدر: | QJM: An International Journal of Medicine. 113:404-410 |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Myocarditis, Adolescent, Fever, 030231 tropical medicine, Encephalopathy, Fluorescent Antibody Technique, India, Enzyme-Linked Immunosorbent Assay, Scrub typhus, Disease, Polymerase Chain Reaction, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Child, biology, business.industry, Multivesicular Bodies, General Medicine, Middle Aged, Jaundice, bacterial infections and mycoses, medicine.disease, Orientia tsutsugamushi, Cross-Sectional Studies, Logistic Models, Scrub Typhus, Immunoglobulin M, biology.protein, Female, medicine.symptom, business, Nested polymerase chain reaction, Encephalitis |
| الوصف: | Background Scrub typhus was once thought to be a disease of rural origin and was confined to specific pockets in South Asia. Early diagnosis and treatment is extremely important as it is associated with high mortality if left untreated. Aim To delineate the clinical and molecular epidemiology of scrub typhus in patients presenting with acute febrile illness from various parts of India. Methods During the study period of 5 years (October 2013 to October 2018), a total of 1742 patients with acute febrile illness Results A total of 210 (12.1%) patients were diagnosed with scrub typhus. Of these, nested PCR was positive in only 85 patients. Sequencing and phylogenetic analysis showed that the predominant circulating genotypes were Gilliam and Karp. On multivariate analysis, acute respiratory distress syndrome, myocarditis, encephalitis/encephalopathy, jaundice and splenomegaly were significantly more common in those patients who were diagnosed with scrub typhus. A total of 14 patients diagnosed with scrub typhus succumbed to the illness. Conclusion Patients with fever, headache, pulmonary manifestations, CNS manifestations, myocarditis, transaminitis or thrombocytopenia presenting in the monsoon and post-monsoon season should be evaluated for scrub typhus irrespective of the geographical location in India. |
| تدمد: | 1460-2393 1460-2725 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2541383b0bf1e8ef42e2a6096a7e36Test https://doi.org/10.1093/qjmed/hcz308Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ba2541383b0bf1e8ef42e2a6096a7e36 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602393 14602725 |
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