Disease Control Rate at 8 Weeks Predicts Subsequent Survival in Platinum-Treated Extensive Stage Small-Cell Lung Cancer: Results From the Southwest Oncology Group (SWOG) Database
| العنوان: | Disease Control Rate at 8 Weeks Predicts Subsequent Survival in Platinum-Treated Extensive Stage Small-Cell Lung Cancer: Results From the Southwest Oncology Group (SWOG) Database |
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| المؤلفون: | Thomas J. Semrad, Philip C. Mack, James Moon, Karen Kelly, Primo N. Lara, Barbara J. Gitlitz, Mary W. Redman, Jeffrey Warren Allen, David R. Gandara |
| المصدر: | Lara, PN; Moon, J; Redman, MW; Semrad, TJ; Kelly, K; Allen, J; et al.(2016). Disease Control Rate at 8 Weeks Predicts Subsequent Survival in Platinum-Treated Extensive Stage Small-Cell Lung Cancer: Results from the Southwest Oncology Group (SWOG) Database. Clinical Lung Cancer, 17(2), 113-118. doi: 10.1016/j.cllc.2015.09.003. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/50n8x82cTest Clinical lung cancer, vol 17, iss 2 |
| بيانات النشر: | Elsevier BV, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, Cancer Research, Tumor assessment, Lung Neoplasms, Databases, Factual, Investigational, Platinum Compounds, computer.software_genre, Targeted therapy, Clinical trials, 0302 clinical medicine, Landmark analysis, Receptors, Antineoplastic Combined Chemotherapy Protocols, 80 and over, Medicine, Disease control rate, Prospective Studies, Carcinoma, Small Cell, Prospective cohort study, Lung, Cancer, Aged, 80 and over, Database, Vascular Endothelial Growth Factor, Therapies, Investigational, Lung Cancer, Hazard ratio, Middle Aged, Prognosis, humanities, Treatment Outcome, 030220 oncology & carcinogenesis, Population study, Female, Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Recombinant Fusion Proteins, Clinical Sciences, Oncology and Carcinogenesis, Outcomes, Small-cell lung cancer, Article, Databases, Young Adult, 03 medical and health sciences, Clinical Research, Internal medicine, Humans, Oncology & Carcinogenesis, Extensive stage, Lung cancer, Factual, Survival analysis, Aged, Neoplasm Staging, L-Lactate Dehydrogenase, business.industry, Proportional hazards model, Carcinoma, Small Cell, medicine.disease, Survival Analysis, Patient Outcome Assessment, Clinical trial, Receptors, Vascular Endothelial Growth Factor, 030104 developmental biology, Therapies, Topotecan, business, computer |
| الوصف: | © 2016 Elsevier Inc. Background Overall response rate is frequently used as an end point in phase 2 trials of platinum-treated extensive stage (ES) small-cell lung cancer (SCLC). We hypothesized that disease control rate (DCR) would be a superior surrogate for subsequent survival outcomes. Methods Updated patient-level data from Southwest Oncology Group (SWOG) trials in second- and/or third-line ES-SCLC patients were pooled. Landmark analysis was performed among patients alive at 8 weeks for overall survival (OS) measured from the 8-week landmark. Association of clinical prognostic factors with DCR was assessed using logistic regression. A Cox proportional hazard model was used to assess the associations between DCR at the landmark time and subsequent OS, adjusted for prognostic factors. Results Of the 319 ES-SCLC patients, 263 were alive at the 8-week landmark and constituted the pooled study population. Only 8 patients had a response. Disease control at 8 weeks was seen in 98 patients. Bivariate analysis of OS from the 8-week landmark revealed that DCR (hazard ratio [HR], 0.47; P |
| وصف الملف: | application/pdf |
| تدمد: | 1525-7304 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94c08f9baa1812fd92ce4d43c6fd3c0Test https://doi.org/10.1016/j.cllc.2015.09.003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b94c08f9baa1812fd92ce4d43c6fd3c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15257304 |
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