Fertaric Acid Protects from Octylphenol-Related Hepatotoxicity in Rats: Biochemical, Molecular, and Histopathological Studies
| العنوان: | Fertaric Acid Protects from Octylphenol-Related Hepatotoxicity in Rats: Biochemical, Molecular, and Histopathological Studies |
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| المؤلفون: | Mahmoud S. Arbid, Khaled M. M. Koriem |
| المصدر: | Journal of Dietary Supplements. 16:152-165 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Bilirubin, Antioxidants, Rats, Sprague-Dawley, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Phenols, Internal medicine, Lactate dehydrogenase, medicine, Animals, Pharmacology (medical), Aspartate Aminotransferases, chemistry.chemical_classification, 030109 nutrition & dietetics, Nutrition and Dietetics, L-Lactate Dehydrogenase, biology, Glutathione peroxidase, Acid phosphatase, Alanine Transaminase, DNA, gamma-Glutamyltransferase, 030229 sport sciences, Malondialdehyde, Rats, Oxidative Stress, Endocrinology, Liver, chemistry, Catalase, biology.protein, Chemical and Drug Induced Liver Injury, Corn oil, Food Science |
| الوصف: | The endocrine-disrupting chemical 4-tert-octylphenol (OP) can mimic estrogen and testosterone hormones and threaten health; fertaric acid (FA) is a hydroxycinnamic acid found in grapefruit. This study aimed to investigate whether FA has a protective effect on 4-tert-octylphenol-related hepatotoxicity. Thirty male albino rats were divided into 5 equal groups of 6 rats each as follows: control group-administrated orally with 1 ml saline 3 days/week for 4 weeks; corn oil group-administrated orally with 1 ml corn oil 3 days/week for 4 weeks; FA-treated group-administrated orally with FA (45 mg /kg body weight) dissolved in saline 3 days/week for 4 weeks; OP-treated group-administrated orally with OP (40 mg /kg body weight) dissolved in corn oil 3 days/week for 4 weeks; FA + OP-treated group-administrated orally with FA (45 mg /kg body weight) dissolved in saline 3 days/week for 4 weeks then administrated orally with OP (40 mg/kg body weight) dissolved in corn oil 3 days/week for another 4 weeks. The results obtained showed that OP-exposed rats had significant increase in serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase, lactate dehydrogenase, bilirubin, serum and liver tumor necrosis factor-α, interleukin-1β and malondialdehyde, serum interleukin-6 and interleukin-10 and significant decrease in serum alkaline phosphatase, acid phosphatase, serum and liver superoxide dismutase, glutathione peroxidase, and catalase. OP caused an inhibitory action on the gene expression of liver proteins. Rats treated with FA before OP exposure had near-normal values. In addition, FA prevented the degradation of liver deoxyribonucleic acid (DNA), and DNA reformation occurred. In conclusion, FA protects from dangerous OP-related hepatic effects, and these results were supported by molecular and histological investigations. |
| تدمد: | 1939-022X 1939-0211 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d3feacb56a7b2bdad9a4741ed9691aTest https://doi.org/10.1080/19390211.2018.1443190Test |
| رقم الانضمام: | edsair.doi.dedup.....b8d3feacb56a7b2bdad9a4741ed9691a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939022X 19390211 |
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