C-C chemokines, IL-16, and soluble antiviral factor activity are increased in cloned T cells from subjects with long-term nonprogressive HIV infection
| العنوان: | C-C chemokines, IL-16, and soluble antiviral factor activity are increased in cloned T cells from subjects with long-term nonprogressive HIV infection |
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| المؤلفون: | Enrico Scala, D Offizi, G., Rosso, R., Turriziani, O., Ferrara, R., Mazzone, A. M., Antonelli, G., Aiuti, F., Paganelli, R. |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | The American Association of Immunologists, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | A combination of three beta, or C-C, chemokines, as well as IL-16, have been shown to inhibit HIV replication in vitro. Cellular antiviral factor is a more potent agent, and acts on all HIV strains. All are mainly, but not exclusively, produced by CD8+ T cells, both in HIV+ and healthy subjects. We studied the production of these HIV-suppressive factors in patients with HIV infection at different stages of disease. No difference in production by PBMC stimulated with PHA has been observed in asymptomatic HIV+, long-term nonprogressors (LTnP), and AIDS patients. When T cell line supernatants from these three groups were studied, no significant difference was found for C-C chemokines or IL-16 production, and viral suppression. However, T cell clones from LTnP secreted higher levels of all three chemokines, IL-16, and exerted a stronger inhibition on HIV replication. CD8+ clones showed a higher production than CD4+ clones. These clones were able to produce all antiviral factors irrespective of the secretion of type 1 or type 2 cytokines. The antiviral activities were not correlated, implying that viral suppression did not depend solely on C-C chemokines or IL-16. We postulate that all factors are needed to prevent HIV disease progression. |
| تدمد: | 1550-6606 0022-1767 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b54dfad1081018724bde9b1bedd248Test https://doi.org/10.4049/jimmunol.158.9.4485Test |
| رقم الانضمام: | edsair.doi.dedup.....b8b54dfad1081018724bde9b1bedd248 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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