Paternal bisphenol A exposure induces testis and sperm pathologies in mice offspring: Possibly due to oxidative stress?
| العنوان: | Paternal bisphenol A exposure induces testis and sperm pathologies in mice offspring: Possibly due to oxidative stress? |
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| المؤلفون: | Mohamed A. Al-Griw, Naser M. Salama, Wafa S. Alansari, Ghalia Shamlan, Bashir A. Lwaleed, Afnan M. Alnajeebi, Abdul Hakim Elnfati, Rabia Alghazeer, Areej A. Eskandrani, Nouf Abubakr Babteen |
| المصدر: | Saudi Journal of Biological Sciences, Vol 28, Iss 1, Pp 948-955 (2021) Saudi Journal of Biological Sciences |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, endocrine system, Multigenerational, Sperm quality, Offspring, Motility, Biology, medicine.disease_cause, 01 natural sciences, Andrology, 03 medical and health sciences, medicine, Endocrine system, Pathological, Endocrine disruptors, lcsh:QH301-705.5, urogenital system, Testis architecture, Sperm, Phenotype, BPA, 030104 developmental biology, lcsh:Biology (General), Oxidative stress, Original Article, General Agricultural and Biological Sciences, Transgenerational, Corn oil, 010606 plant biology & botany |
| الوصف: | Bisphenol A (BPA), an endocrine and metabolic disruptor, is widely used to manufacture polycarbonate plastics and epoxy resins. Accumulating evidence suggests that paternal BPA exposure adversely affects male germlines and results in atypical reproductive phenotypes that might persist for generations to come. Our study investigated this exposure on testicular architecture and sperm quality in mouse offspring, and characterised underlying molecular mechanism(s). A total of 18 immature male Swiss albino mice (3.5 weeks old) were randomly divided into three groups and treated as follows: Group I, no treatment (sham control); Group II, sterile corn oil only (vehicle control); Group III, BPA (400 μg/kg) in sterile corn oil. At 9.5 weeks old, F0 males were mated with unexposed females. F0 offspring (F1 generation) were monitored for postnatal development for 10 weeks. At 11.5 weeks old, the animals were sacrificed to examine testicular architecture, sperm parameters, including DNA integrity, and oxidative stress biomarkers. Results showed that BPA significantly induced changes in the body and testis weights of the F0 and F1 generation BPA lineages compared to F0 and F1 generation control lineages. A decrease in sperm count and motility with further, increased sperm abnormalities, no or few sperm DNA alterations and elevated levels of MDA, PC and NO were recorded. Similar effects were found in BPA exposed F0 males, but were more pronounced in the F0 offspring. In addition, BPA caused alterations in the testicular architecture. These pathological changes extended transgenerationally to F1 generation males’ mice, but the pathological changes were more pronounced in the F1 generation. Our findings demonstrate that the biological and health BPA impacts do not end in paternal adults, but are passed on to offspring generations. Hence, linking observed testis and sperm abnormalities in the F1 generation to BPA exposure of their parental line was evident in this work. The findings also illustrate that oxidative stress appears to be a molecular component of the testis and sperm pathologies. |
| وصف الملف: | text |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a0e432364881a7f32e3d801534c4aeTest http://www.sciencedirect.com/science/article/pii/S1319562X20305647Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b7a0e432364881a7f32e3d801534c4ae |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |