Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial
| العنوان: | Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial |
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| المؤلفون: | Mitsuhiro Katashima, Tohru Yamaguchi, Sumio Kondo, Masanobu Hibi, Yuki Mitsui, Sayaka Hari |
| المصدر: | Nutrients, Vol 11, Iss 9, p 2126 (2019) Nutrients Volume 11 Issue 9 |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, insulin, Time Factors, endocrine system diseases, medicine.medical_treatment, Blood sugar, 030209 endocrinology & metabolism, lcsh:TX341-641, Carbohydrate metabolism, Article, 03 medical and health sciences, 0302 clinical medicine, Glucagon-Like Peptide 1, Internal medicine, Glucose Intolerance, Insulin Secretion, Medicine, Humans, 030212 general & internal medicine, glucose, Meals, Glucose tolerance test, Meal, Nutrition and Dietetics, Cross-Over Studies, CGMS, medicine.diagnostic_test, business.industry, Insulin, Blood Glucose Self-Monitoring, Area under the curve, nutritional and metabolic diseases, Fasting, Glucose Tolerance Test, Impaired fasting glucose, medicine.disease, Diet, Endocrinology, Blood chemistry, Area Under Curve, meal frequency, business, GLP-1, lcsh:Nutrition. Foods and food supply, hormones, hormone substitutes, and hormone antagonists, Food Science |
| الوصف: | Effects of meal frequency on blood glucose levels and glucose metabolism were evaluated over 3 days in adult males with normal glucose tolerance (NGT, n = 9) or impaired fasting glucose (IFG, n = 9) in a randomized, crossover comparison study. Subjects were provided with an isocaloric diet 3 times daily (3M) or 9 times daily (9M). Blood glucose was monitored on Day 3 using a continuous glucose monitoring system, and subjects underwent a 75-g oral glucose tolerance test (OGTT) on Day 4. Daytime maximum blood glucose, glucose range, duration of glucose &ge 180 mg/dL, and nighttime maximum glucose were significantly lower in the NGT/9M condition than in the NGT/3M condition. Similar findings were observed in the IFG subjects, with a lower daytime and nighttime maximum glucose and glucose range, and a significantly higher daytime minimum glucose in the 9M condition than in the 3M condition. The OGTT results did not differ significantly between NGT/3M and NGT/9M conditions. In contrast, the incremental area under the curve tended to be lower and the maximum plasma glucose concentration was significantly lower in the IFG/9M condition than in the IFG/3M condition. In IFG subjects, the 9M condition significantly improved glucose metabolism compared with the 3M condition. Higher meal frequency may increase glucagon-like peptide 1 secretion and improve insulin secretion. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b788a226f0daf8e433030f4999c9483aTest https://www.mdpi.com/2072-6643/11/9/2126Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b788a226f0daf8e433030f4999c9483a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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