NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus
| العنوان: | NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus |
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| المؤلفون: | George P. Chrousos, Ioannis Papassotiriou, Jeanette Wahlberg, Alexandra Margeli, Nektaria Papadopoulou-Marketou, Christina Kanaka-Gantenbein |
| المصدر: | Journal of Diabetes Research, Vol 2017 (2017) Journal of Diabetes Research |
| بيانات النشر: | Hindawi Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Heart Diseases, Article Subject, Systole, Endocrinology, Diabetes and Metabolism, Renal function, 030209 endocrinology & metabolism, Endocrinology and Diabetes, 030204 cardiovascular system & hematology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Prehypertension, Diabetic nephropathy, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Lipocalin-2, Internal medicine, Diabetes mellitus, medicine, Albuminuria, Humans, Diabetic Nephropathies, Prospective Studies, Young adult, Child, Prospective cohort study, Type 1 diabetes, lcsh:RC648-665, Predictive marker, business.industry, medicine.disease, Diabetes Mellitus, Type 1, Child, Preschool, Hypertension, Endokrinologi och diabetes, Female, Kidney Diseases, business, Biomarkers, Research Article |
| الوصف: | Aims. Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardio-renal dysfunction in T1D. Methods. Two T1D patient groups participating in two-centre prospective cohorts were studied. Group A consisted of 57 participants aged 13.9 years (SD: 3.1) and group B consisted of 59 patients aged 28.0 years (SD: 4.4). Forty-nine healthy children [age: 10.5 years (SD: 6.6)] and 18 healthy adults [age 27.7 years (SD: 4.2)] served as controls. Serum concentrations of NGAL (ELISA) were determined, and SAP and DAP were examined (SAP and DAP also expressed as z-scores in the younger group). Results. NGAL correlated positively with SAP in both patient groups (P=0.020 and P=0.031, resp.) and SAP z-score (P=0.009) (group A) and negatively with eGFR in both groups (P<0.001 and P<0.001, resp.). Conclusions. NGAL may be proposed as a biomarker of early renal dysfunction even in nonalbuminuric T1D patients, since it was strongly associated with renal function decline and increasing systolic arterial pressure even at prehypertensive range in people with T1D, in a broad age range. |
| وصف الملف: | application/pdf; text/xhtml |
| تدمد: | 2314-6753 2314-6745 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b700e14274541bb18870615d6b857507Test https://doi.org/10.1155/2017/7526919Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b700e14274541bb18870615d6b857507 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146753 23146745 |
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