Biocompatible modified water as a non-pharmaceutical approach to prevent metabolic syndrome features in obesogenic diet-fed mice
| العنوان: | Biocompatible modified water as a non-pharmaceutical approach to prevent metabolic syndrome features in obesogenic diet-fed mice |
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| المؤلفون: | Valérie Scheuermann, Karen Lambert, Franck Aimond, Claire Gondeau, Martine Daujat-Chavanieu, Philippe Briolotti |
| المساهمون: | Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), MORNET, Dominique |
| المصدر: | Food and Chemical Toxicology Food and Chemical Toxicology, Elsevier, 2020, 141, pp.111403. ⟨10.1016/j.fct.2020.111403⟩ Food and Chemical Toxicology, 2020, 141, pp.111403. ⟨10.1016/j.fct.2020.111403⟩ |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Hepatic steatosis, Inflammation, Biocompatible Materials, Toxicology, Diet, High-Fat, 03 medical and health sciences, Mice, 0404 agricultural biotechnology, Insulin resistance, Internal medicine, medicine, Tap water, Animals, Obesity, 030304 developmental biology, 2. Zero hunger, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Metabolic Syndrome, 0303 health sciences, business.industry, Drinking Water, Lipogenesis, Skeletal muscle, 04 agricultural and veterinary sciences, General Medicine, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, medicine.disease, 040401 food science, High fat high sucrose diet, Liver Glycogen, Mice, Inbred C57BL, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Endocrinology, medicine.anatomical_structure, Basal Metabolism, Metabolic syndrome, Steatosis, medicine.symptom, Insulin Resistance, Hepatic fibrosis, business, Biocompatible modified water, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Dyslipidemia, Biomarkers, Food Science |
| الوصف: | International audience; The prevalence of metabolic syndrome (MetS), elevating cardiovascular risks, is increasing worldwide, with no available global therapeutic options. The intake of plain, mineral or biocompatible modified waters was shown to prevent some MetS features. This study was designed to analyze, in mice fed a high fat and sucrose diet (HFSD), the effects on MetS features of the daily intake of a reverse osmosed, weakly remineralized, water (OW) and of an OW dynamized by a physical processing (ODW), compared to tap water (TW). The HFSD was effective at inducing major features of MetS such as obesity, hepatic steatosis and inflammation, blood dyslipidemia, systemic glucose intolerance and muscle insulin resistance. Compared to TW, OW intake decreased hepatic fibrosis and inflammation, and mitigated hepatic steatosis and dyslipidemia. ODW intake further improved skeletal muscle insulin sensitivity and systemic glucose tolerance. This study highlights the deleterious metabolic impacts of the daily intake of TW, in combination with a high energy diet, and its possible involvement in MetS prevalence increase. In addition, it demonstrates that biocompatible modified water may be promising non-pharmaceutical, cost-effective tools for nutritional approaches in the treatment of MetS. |
| وصف الملف: | application/pdf |
| تدمد: | 1873-6351 0278-6915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6beee261c8630d6b3856c745e709e08Test https://pubmed.ncbi.nlm.nih.gov/32387306Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b6beee261c8630d6b3856c745e709e08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18736351 02786915 |
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