Cardiac resynchronization therapy with a defibrillator (CRTd) in failing heart patients with type 2 diabetes mellitus and treated by glucagon-like peptide 1 receptor agonists (GLP-1 RA) therapy vs. conventional hypoglycemic drugs: arrhythmic burden, hospitalizations for heart failure, and CRTd responders rate
| العنوان: | Cardiac resynchronization therapy with a defibrillator (CRTd) in failing heart patients with type 2 diabetes mellitus and treated by glucagon-like peptide 1 receptor agonists (GLP-1 RA) therapy vs. conventional hypoglycemic drugs: arrhythmic burden, hospitalizations for heart failure, and CRTd responders rate |
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| المؤلفون: | Ciro Mauro, Giuseppe Paolisso, Claudio de Lucia, Michelangela Barbieri, Raffaele Marfella, Celestino Sardu, Maria Rosaria Rizzo, Antonio Ruocco, Matteo Santamaria, Cosimo Sacra, Pasquale Paolisso |
| المساهمون: | Sardu, Celestino, Paolisso, Pasquale, Sacra, Cosimo, Santamaria, Matteo, de Lucia, Claudio, Ruocco, Antonio, Mauro, Ciro, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Barbieri, Michelangela, Marfella, Raffaele |
| المصدر: | Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-16 (2018) Cardiovascular Diabetology |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Blood Glucose, Male, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030204 cardiovascular system & hematology, Systemic inflammation, Ventricular Function, Left, Cardiac Resynchronization Therapy, 0302 clinical medicine, Risk Factors, Prospective Studies, Prospective cohort study, Original Investigation, Ejection fraction, Middle Aged, Defibrillators, Implantable, Treatment Outcome, Italy, Disease Progression, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Cardiac resynchronization therapy, Electric Countershock, 030209 endocrinology & metabolism, Incretins, Patient Readmission, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Cardiac Resynchronization Therapy Devices, Angiology, Aged, Heart Failure, business.industry, Type 2 Diabetes Mellitus, Arrhythmias, Cardiac, Recovery of Function, medicine.disease, Diabetes Mellitus, Type 2, lcsh:RC666-701, Heart failure, business, Biomarkers |
| الوصف: | Objectives To evaluate clinical outcomes in patients with diabetes, treated by cardiac resynchronization therapy with a defibrillator (CRT-d), and glucagon-like peptide 1 receptor agonists (GLP-1 RA) in addition to conventional hypoglycemic therapy vs. CRTd patients under conventional hypoglycemic drugs. Background Patients with diabetes treated by CRTd experienced an amelioration of functional New York Association Heart class, reduction of hospital admissions, and mortality, in a percentage about 60%. However, about 40% of CRTd patients with diabetes experience a worse prognosis. Materials and methods We investigated the 12-months prognosis of CRTd patients with diabetes, previously treated with hypoglycemic drugs therapy (n 271) vs. a matched cohort of CRTd patients with diabetes treated with GLP-1 RA in addition to conventional hypoglycemic therapy (n 288). Results At follow up CRTd patients with diabetes treated by GLP-1 RA therapy vs. CRTd patients with diabetes that did not receive GLP-1 RA therapy, experienced a significant reduction of NYHA class (p value Conclusions GLP-1 RA drugs in addition to conventional hypoglycemic therapy may significantly reduce systemic inflammation and circulating BNP levels in CRTd patients with diabetes, leading to a significant improvement of LVEF and of the 6 min walking test, and to a reduction of the arrhythmic burden. Consequently, GLP-1 RA drugs in addition to conventional hypoglycemic therapy may reduce hospital admissions for heart failure worsening, by increasing CRTd responders rate. Trial registration NCT03282136. Registered 9 December 2017 “retrospectively registered” |
| اللغة: | English |
| تدمد: | 1475-2840 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b637835afe49190913e16a04ccabae61Test http://link.springer.com/article/10.1186/s12933-018-0778-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b637835afe49190913e16a04ccabae61 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752840 |
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