PD ‐1 and PD‐L1 expression in Kaposi sarcoma: A comparative study according to the pathological stage and clinical characteristics
| العنوان: | |
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| المؤلفون: | Mi Woo Lee, Sung Eun Chang, Chang Jin Jung, Young Jae Kim, Woo Jin Lee, Chong Hyun Won, Jee Ho Choi |
| المصدر: | Journal of Cutaneous Pathology. 48:221-228 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Skin Neoplasms, Histology, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Dermatology, B7-H1 Antigen, Pathology and Forensic Medicine, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Stage (cooking), Sarcoma, Kaposi, Pathological, Aged, Neoplasm Staging, Aged, 80 and over, biology, business.industry, Immune escape, Immunotherapy, Middle Aged, medicine.disease, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Tumor progression, 030220 oncology & carcinogenesis, biology.protein, Female, Pd l1 expression, Sarcoma, Antibody, business |
| الوصف: | Background Kaposi sarcoma (KS) is a mesenchymal tumor with distinct histopathological features according to tumor progression. Programmed death-1 (PD-1) and its ligand PD-L1 play major roles in the immune escape strategy of tumors. Objectives This study evaluated expression of PD-1 and PD-L1 in various stages of KS and investigated associations between their expression and clinical characteristics. Methods Fifty cases with histopathologically diagnosed KS were classified as early or late stage. These specimens were stained with anti-PD-1 and anti-PD-L1 antibodies. The extent of expression in the intratumoral and peri-tumoral areas was judged by two dermatopathologists. Results PD-1 and PD-L1 were expressed in 72.2% (13/18) and 11.1% (2/18) of early-stage cases, respectively, compared with 43.8% (14/32) and 28.1% (9/32) of late-stage cases, respectively. At the late stage, PD-1 expression was significantly higher in the peri-tumoral area than in the intratumoral area (P = 0.001). PD-1 expression in the intratumoral area was significantly higher at the early stage than at the late stage (P = 0.013). PD-L1 expression in the peri-tumoral area was significantly higher at the late stage than at the early stage (P = 0.038). Conclusions The pattern of PD-1 and PD-L1 expression differs according to the stage of KS, but is unaffected by clinical variables. |
| تدمد: | 1600-0560 0303-6987 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fea3f9a0410bd2be77d17cfecfcc2cTest https://doi.org/10.1111/cup.13841Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b5fea3f9a0410bd2be77d17cfecfcc2c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000560 03036987 |
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