Understanding the increased risk of infections in diabetes: innate and adaptive immune responses in type 1 diabetes
| العنوان: | Understanding the increased risk of infections in diabetes: innate and adaptive immune responses in type 1 diabetes |
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| المؤلفون: | Niels P. Riksen, Anna W M Janssen, Leo A. B. Joosten, M. G. Netea, Rinke Stienstra, Alain J. van Gool, Martin Jaeger, Cees J. Tack |
| المصدر: | Metabolism: Clinical and Experimental, 121 Metabolism-Clinical and Experimental, 121 Metabolism: Clinical and Experimental 121 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Cytokine response, Adaptive immune system, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Adaptive Immunity, Cohort Studies, Voeding, Metabolisme en Genomica, 0302 clinical medicine, Endocrinology, Risk Factors, Candida albicans, Child, Netherlands, biology, Innate immune system, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6], Middle Aged, Acquired immune system, Metabolism and Genomics, Cytokine, Type 1 diabetes, Metabolisme en Genomica, Child, Preschool, Cytokines, Nutrition, Metabolism and Genomics, Female, Adult, medicine.medical_specialty, Adolescent, 030209 endocrinology & metabolism, Glycemic Control, Infections, 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, Immune system, Voeding, Internal medicine, Diabetes mellitus, medicine, Humans, Nutrition, Aged, business.industry, Infant, Newborn, Infant, biology.organism_classification, medicine.disease, Immunity, Innate, 030104 developmental biology, Diabetes Mellitus, Type 1, Case-Control Studies, Immunology, business, Ex vivo |
| الوصف: | Aims: Patients with diabetes have a higher incidence of infections with Candida albicans, Staphylococcus aureus and Mycobacterium tuberculosis, yet factors contributing to this increased risk are largely unknown. We hypothesize that altered innate and adaptive immune responses during diabetes contribute to an increased susceptibility to infections. Materials and methods: We studied cytokine responses to ex vivo pathogenic stimulations in a cohort with type 1 diabetes (n = 243) and non-diabetic healthy control subjects (n = 56) using isolated peripheral blood mononuclear cells (PBMCs). Clinical phenotypical data including BMI, duration of diabetes, and HbA1c levels were collected and related to the cytokine production capacity. Results: Adjusted for age, sex and BMI, the presence of diabetes was associated with significantly lower IL-1β, IL-6, TNF-α, and IL-17 production upon ex vivo stimulation of PBMCs with C. albicans and S. aureus (all, p < 0.05). In response to stimulation with M. tuberculosis only IL-17 (p < 0.001) was lower in patients with diabetes. Patients with the shortest diabetes duration had a significant lower IL-1β, IL-6 and TNF-α production (all, p < 0.01) after M. tuberculosis stimulation. Older patients had a significant lower IFN-γ (p < 0.05) production after stimulation with all three pathogens. HbA1c levels and BMI had no significant impact on cytokine production. Conclusions: PBMCs of patients with type 1 diabetes demonstrate significantly lower cytokine production in response to stimulation with several pathogens, which likely explain, at least in part, the increased susceptibility for these infections. |
| وصف الملف: | application/octet-stream; application/pdf |
| تدمد: | 1532-8600 0026-0495 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5af130a4c61e97999dd5be3a7e9441cTest https://pubmed.ncbi.nlm.nih.gov/33971203Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....b5af130a4c61e97999dd5be3a7e9441c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15328600 00260495 |
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