Tardive Reactivation of Progressive Multiple Sclerosis During Treatment with Biotin
| العنوان: | Tardive Reactivation of Progressive Multiple Sclerosis During Treatment with Biotin |
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| المؤلفون: | Yvan Vaschalde, Alexis Demas, Jean-Philippe Cochin, Pierre Labauge, Bertrand Bourre, Clémence Hardy |
| المساهمون: | Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) (GHH), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Salvy-Córdoba, Nathalie |
| المصدر: | Neurology and Therapy Neurology and Therapy, 2020, 9 (1), pp.181-185. ⟨10.1007/s40120-019-00175-2⟩ Neurology and Therapy, Vol 9, Iss 1, Pp 181-185 (2019) Neurology and Therapy, Springer Healthcare, 2020, 9 (1), pp.181-185. ⟨10.1007/s40120-019-00175-2⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neurology, Adverse drug reaction, Pseudo-tumoral lesion, Biotin, Case Report, Bioinformatics, lcsh:RC346-429, Lesion, Multiple sclerosis, 03 medical and health sciences, Myelin, 0302 clinical medicine, Cerebrospinal fluid, Medicine, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030212 general & internal medicine, Young adult, 10. No inequality, lcsh:Neurology. Diseases of the nervous system, Autoimmune disease, business.industry, medicine.disease, 3. Good health, medicine.anatomical_structure, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, MRI |
| الوصف: | International audience; Multiple sclerosis (MS) is a common autoimmune disease of the central nervous system, causing neurological disability in young adults. A growing understanding of its immunopathogenesis has led to an expanding array of therapies. Notable new advances in disease-modifying therapies for relapsing forms of multiple sclerosis that are based on anti-inflammatory activity have recently been developed. Management of progressive MS is still challenging. Data published in 2014 suggested that daily high doses of biotin, a vitamin involved in myelin synthesis, might have a beneficial impact on disability and progression in progressive MS. However, some patients worsened while on biotin without any clear explanation for this effect. We report the case of a 41-year-old patient suffering from primary progressive (PP) MS who presented after 16 months of treatment with high doses of biotin (QIZENDAY) with worsening of his Expanding Disability Status Scale (EDSS) score and the appearance of a symptomatic new T2 pseudo-tumoural lesion on brain magnetic resonance imaging (MRI), suggestive of tardive inflammatory reactivation possibly due to the biotin. The newer and more effective therapies for MS are, however, associated with risks that necessitate an active management strategy and continuous vigilance. Physicians should be aware of iatrogenic neurological complications and the possible paradoxical effects of biotin. Future treatment approaches to progressive MS must include identification of a biomarker of disease activity. The study of neurofilaments in the cerebrospinal fluid (CSF) and the serum could be of interest when determining the optimal treatment strategy. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2193-8253 2193-6536 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5accb28fc3a3fcd9e7a3c5c8f66ba76Test https://hal.umontpellier.fr/hal-03388283/file/40120_2019_Article_175.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b5accb28fc3a3fcd9e7a3c5c8f66ba76 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21938253 21936536 |
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