Initiation of New Glucose-Lowering Therapies May Act to Reduce Physical Activity Levels: Pooled Analysis From Three Randomized Trials
| العنوان: | Initiation of New Glucose-Lowering Therapies May Act to Reduce Physical Activity Levels: Pooled Analysis From Three Randomized Trials |
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| المؤلفون: | Thomas Yates, Jack A. Sargeant, James A. King, Joe Henson, Charlotte L. Edwardson, Emma Redman, Gaurav S. Gulsin, Emer M. Brady, Ehtasham Ahmad, David J. Stensel, David R. Webb, Gerry P. McCann, Kamlesh Khunti, Melanie J. Davies |
| المصدر: | Diabetes Care. 45:2749-2752 |
| بيانات النشر: | American Diabetes Association, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Glycated Hemoglobin, Advanced and Specialized Nursing, Dipeptidyl-Peptidase IV Inhibitors, Endocrinology, Diabetes and Metabolism, Sitagliptin Phosphate, Liraglutide, Glucagon-Like Peptide-1 Receptor, Glucose, Diabetes Mellitus, Type 2, Internal Medicine, Humans, Hypoglycemic Agents, Exercise, Randomized Controlled Trials as Topic |
| الوصف: | OBJECTIVE Sodium–glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) reduce body weight and improve cardiometabolic health, but their effect on physical activity is unknown. RESEARCH DESIGN AND METHODS We pooled data (n = 148) from three randomized trials to investigate the effect of empagliflozin (SGLT2i) and liraglutide (GLP-1RA), in comparison with sitagliptin (dipeptidyl peptidase 4 inhibitor) and dietary therapies, on accelerometer-assessed physical activity. RESULTS Liraglutide (mean −1,144 steps/day; 95% CI −2,069 to −220), empagliflozin (−1,132 steps/day; −1,739, −524), and sitagliptin (−852 steps/day; −1,625, −78) resulted in reduced total daily physical activity after 6 months (P < 0.01 vs. control). Moderate- to vigorous-intensity physical activity was also reduced. Dietary interventions led to no change or an increase in physical activity. CONCLUSIONS The initiation of all glucose-lowering therapies was associated with reduced physical activity, warranting further investigation. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a441de879f408c8637160a90273b87Test https://doi.org/10.2337/dc22-0888Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b5a441de879f408c8637160a90273b87 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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