Maternal serum apelin and YKL-40 levels in early and late-onset pre-eclampsia
| العنوان: | Maternal serum apelin and YKL-40 levels in early and late-onset pre-eclampsia |
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| المؤلفون: | Riza Madazli, Mine Kucur, Abdullah Tuten, Metehan Imamoglu, Mehmet Aytac Yuksel, Abdullah Serdar Acikgoz, Ozlem Balci Ekmekci, Nevin Yilmaz, Mahmut Oncul |
| المصدر: | Hypertension in Pregnancy. 33:467-475 |
| بيانات النشر: | Informa UK Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Adipokine, Late onset, Normal pregnancy, Young Adult, Adipokines, Pre-Eclampsia, Pregnancy, Lectins, Internal medicine, Internal Medicine, medicine, Humans, Chitinase-3-Like Protein 1, Young adult, Eclampsia, business.industry, Case-control study, Obstetrics and Gynecology, medicine.disease, Apelin, Endocrinology, Case-Control Studies, Intercellular Signaling Peptides and Proteins, Female, business, Biomarkers |
| الوصف: | The aim of the present study is to investigate whether alterations in the serum levels of apelin and YKL-40 differ between early and late onset pre-eclampsia and whether there is a correlation between apelin and YKL-40 in women who subsequently develop early and late pre-eclampsia.A total number of 80 pregnant women, 40 with normal pregnancy and 40 with pre-eclampsia, were included in the present study. Both the normal pregnant and pre-eclamptic subjects were subdivided into two groups. Serum YKL-40 and apelin concentrations were measured.Mean maternal serum YKL-40 levels were both lower in women who subsequently developed early (87.45 ± 3.07 versus 103.40 ± 4.29) or late (96.43 ± 4.06 versus 99.87 ± 3.63) pre-eclampsia than those who remained normotensive. The difference was significant in early-onset preeclamptic women (p 0.05) rather than late-onset pre-eclamptic ones (p 0.05). Mean maternal serum apelin levels were both higher in women who subsequently developed early (8.6 ± 3.6 versus 5.7 ± 1.2) or late (9.6 ± 2.5 versus 8.1 ± 1.8) pre-eclampsia than those who remained normotensive. The difference was significant in early-onset preeclamptic women (p 0.05) rather than late-onset pre-eclamptic ones (p 0.05). There was a significant negative correlation between serum apelin and YKL-40 levels (r = -0.48, p = 0.001).Circulating levels of apelin are significantly increased in early-onset pre-eclampsia, indicating the role of apelin in the discrimination of the early-onset of pre-eclampsia. On the other hand, maternal serum YKL-40 levels are not elavated significantly, indicating that adipose-derived apelin is primarily involved in the vascular pathogenesis of early-onset pre-eclampsia than macrophage-derived YKL-40. |
| تدمد: | 1525-6065 1064-1955 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fc2b8718511fa7c61e1be4a4eff4b3Test https://doi.org/10.3109/10641955.2014.944709Test |
| رقم الانضمام: | edsair.doi.dedup.....b4fc2b8718511fa7c61e1be4a4eff4b3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15256065 10641955 |
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