Cephalic phase secretion of insulin and other enteropancreatic hormones in humans
| العنوان: | Cephalic phase secretion of insulin and other enteropancreatic hormones in humans |
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| المؤلفون: | Bolette Hartmann, Carolyn F. Deacon, Tina Vilsbøll, Filip K. Knop, Simon Veedfald, Jens J. Holst, Astrid Plamboeck |
| المصدر: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 310:G43-G51 |
| بيانات النشر: | American Physiological Society, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Time Factors, Physiology, Denmark, 030209 endocrinology & metabolism, Gastric Inhibitory Polypeptide, Muscarinic Antagonists, Pancreatic Polypeptide, Glucagon, Eating, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Gastric inhibitory polypeptide, Glucagon-Like Peptide 1, Heart Rate, Physiology (medical), Internal medicine, Insulin Secretion, medicine, Humans, Insulin, Pancreatic polypeptide, Intestinal Mucosa, Pancreas, Intestinal Secretions, Hepatology, business.industry, digestive, oral, and skin physiology, Gastroenterology, Vagus Nerve, Cephalic phase, Glucose clamp technique, Postprandial Period, Glucagon-like peptide-1, Ghrelin, Sham feeding, Intestines, 030104 developmental biology, Endocrinology, Glucose Clamp Technique, business, Biomarkers |
| الوصف: | Enteropancreatic hormone secretion is thought to include a cephalic phase, but the evidence in humans is ambiguous. We studied vagally induced gut hormone responses with and without muscarinic blockade in 10 glucose-clamped healthy men (age: 24.5 ± 0.6 yr, means ± SE; body mass index: 24.0 ± 0.5 kg/m2; HbA1c: 5.1 ± 0.1%/31.4 ± 0.5 mmol/mol). Cephalic activation was elicited by modified sham feeding (MSF, aka “chew and spit”) with or without atropine (1 mg bolus 45 min before MSF + 80 ng·kg−1·min−1 for 2 h). To mimic incipient prandial glucose excursions, glucose levels were clamped at 6 mmol/l on all days. The meal stimulus for the MSF consisted of an appetizing breakfast. Participants (9/10) also had a 6 mmol/l glucose clamp without MSF. Pancreatic polypeptide (PP) levels rose from 6.3 ± 1.1 to 19.9 ± 6.8 pmol/l (means ± SE) in response to MSF and atropine lowered basal PP levels and abolished the MSF response. Neither insulin, C-peptide, glucose-dependent insulinotropic polypeptide (GIP), nor glucagon-like peptide-1 (GLP-1) levels changed in response to MSF or atropine. Glucagon and ghrelin levels were markedly attenuated by atropine prior to and during the clamp: at t = 105 min on the atropine (ATR) + clamp (CLA) + MSF compared with the saline (SAL) + CLA and SAL + CLA + MSF days; baseline-subtracted glucagon levels were −10.7 ± 1.1 vs. −4.0 ± 1.1 and −4.7 ± 1.9 pmol/l (means ± SE), P < 0.0001, respectively; corresponding baseline-subtracted ghrelin levels were 303 ± 36 vs. 39 ± 38 and 3.7 ± 21 pg/ml (means ± SE), P < 0.0001. Glucagon and ghrelin levels were unaffected by MSF. Despite adequate PP responses, a cephalic phase response was absent for insulin, glucagon, GLP-1, GIP, and ghrelin. |
| تدمد: | 1522-1547 0193-1857 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bda389c0c16f666c477ebc1e402ea9Test https://doi.org/10.1152/ajpgi.00222.2015Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b4bda389c0c16f666c477ebc1e402ea9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221547 01931857 |
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