Influence of receptor polymorphisms on the response to alpha-adrenergic receptor blockers in pheochromocytoma patients
| العنوان: | Influence of receptor polymorphisms on the response to alpha-adrenergic receptor blockers in pheochromocytoma patients |
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| المؤلفون: | Annika M. A. Berends, Mathieu S. Bolhuis, Ilja M. Nolte, Edward Buitenwerf, Thera P. Links, Henri J. L. M. Timmers, Richard A. Feelders, Elisabeth M. W. Eekhoff, Eleonora P. M. Corssmit, Peter H. Bisschop, Harm R. Haak, Ron H. N. van Schaik, Samira el Bouazzaoui, Bob Wilffert, Michiel N. Kerstens |
| المساهمون: | Microbes in Health and Disease (MHD), Life Course Epidemiology (LCE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Reproductive Origins of Adult Health and Disease (ROAHD), RS: CAPHRI - R1 - Ageing and Long-Term Care, Interne Geneeskunde, Internal medicine, AMS - Musculoskeletal Health, AMS - Tissue Function & Regeneration, Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, AMS - Ageing & Vitality |
| المصدر: | Biomedicines, 10(4):896. MDPI AG Berends, A M A, Bolhuis, M S, Nolte, I M, Buitenwerf, E, Links, T P, Timmers, H J L M, Feelders, R A, Eekhoff, E M W, Corssmit, E P M, Bisschop, P H, Haak, H R, van Schaik, R H N, el Bouazzaoui, S, Wilffert, B & Kerstens, M N 2022, ' Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients ', Biomedicines, vol. 10, no. 4, 896 . https://doi.org/10.3390/biomedicines10040896Test Biomedicines, 10 Biomedicines, 10(4). MDPI Biomedicines; Volume 10; Issue 4; Pages: 896 Biomedicines, 10, 4 |
| بيانات النشر: | MDPI, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | ALPHA(2B)-ADRENERGIC RECEPTOR, HYPERTENSION, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], Medicine (miscellaneous), GENETIC-VARIATION, BLOOD-PRESSURE, personalized medicine, VARIANTS, ADRA2A, pheochromocytoma, General Biochemistry, Genetics and Molecular Biology, ALPHA-1-ADRENERGIC RECEPTOR, paraganglioma, All institutes and research themes of the Radboud University Medical Center, ALPHA(1B)-ADRENERGIC RECEPTOR, single nucleotide polymorphism, adrenergic receptor, alpha-adrenergic receptor blocker, pharmacogenetics, GENOME-WIDE ASSOCIATION, FASTING GLUCOSE |
| الوصف: | Background: Presurgical treatment with an α-adrenergic receptor blocker is recommended to antagonize the catecholamine-induced α-adrenergic receptor mediated vasoconstriction in patients with pheochromocytoma or sympathetic paraganglioma (PPGL). There is, however, a considerable interindividual variation in the dose-response relationship regarding the magnitude of blood pressure reduction or the occurrence of side effects. We hypothesized that genetically determined differences in α-adrenergic receptor activity contribute to this variability in dose-response relationship. Methods: Thirty-one single-nucleotide polymorphisms (SNPs) of the α1A, α1B, α1D adrenoreceptor (ADRA1A, ADRA1B, ADRA1D) and α2A, α2B adrenoreceptor (ADRA2A, ADRA2B) genes were genotyped in a group of 116 participants of the PRESCRIPT study. Haplotypes were constructed after determining linkage disequilibrium blocks. Results: The ADRA1B SNP rs10515807 and the ADRA2A SNPs rs553668/rs521674 were associated with higher dosages of α-adrenergic receptor blocker (p < 0.05) and with a higher occurrence of side effects (rs10515807) (p = 0.005). Similar associations were found for haplotype block 6, which is predominantly defined by rs10515807. Conclusions: This study suggests that genetic variability of α-adrenergic receptor genes might be associated with the clinically observed variation in beneficial and adverse therapeutic drug responses to α-adrenergic receptor blockers. Further studies in larger cohorts are needed to confirm our observations. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2227-9059 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b479b4a58befd91fc49c91713460170fTest https://hdl.handle.net/1887/3563208Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b479b4a58befd91fc49c91713460170f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22279059 |
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