Pancreas and gut hormone responses to oral glucose and intravenous glucagon in cystic fibrosis patients with normal, impaired, and diabetic glucose tolerance
| العنوان: | Pancreas and gut hormone responses to oral glucose and intravenous glucagon in cystic fibrosis patients with normal, impaired, and diabetic glucose tolerance |
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| المؤلفون: | Susanne Lanng, Jens J. Holst, Jørn Nerup, Michael E Røder, Cathrine Ørskov, Christian A. Koch, Birger Thorsteinsson |
| المصدر: | CIÊNCIAVITAE University of Copenhagen Europe PubMed Central |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Cystic Fibrosis, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Glucagon-Like Peptides, Administration, Oral, Gastric Inhibitory Polypeptide, Pancreatic Polypeptide, Glucagon, Impaired glucose tolerance, Diabetes Complications, Endocrinology, Gastric inhibitory polypeptide, Glucagon-Like Peptide 1, Internal medicine, Diabetes mellitus, medicine, Diabetes Mellitus, Pancreatic polypeptide, Humans, Insulin, Intestinal Mucosa, Protein Precursors, Pancreas, Pancreatic hormone, Glucose tolerance test, medicine.diagnostic_test, C-Peptide, business.industry, General Medicine, Glucose Tolerance Test, Middle Aged, medicine.disease, Hormones, Peptide Fragments, Intestines, Glucose, Injections, Intravenous, Female, business, Proinsulin |
| الوصف: | Pancreatic and gut hormone responses to oral glucose, and insulin sensitivity were studied in cystic fibrosis patients with normal (N= 14), impaired (N=4), and diabetic (N= 12) glucose tolerance, and in 10 control subjects, and beta cell responses to oral glucose and intravenous glucagon were compared. Compared to control subjects, initial insulin and C-peptide responses to oral glucose were lower in all patient groups, and decreased with decreasing glucose tolerance. Insulin sensitivity in patients with impaired and diabetic glucose tolerance was lower than in control subjects. The 6 min post-glucagon C-peptide concentration was positively correlated with the initial insulin response to oral glucose. Fasting levels of pancreatic polypeptide, pancreatic glucagon, total glucagon, glucagon-like peptide-1 7-36 amide, and gastric inhibitory polypeptide were normal in all patient groups. Following oral glucose, pancreatic polypeptide responses were absent in all patients, suppressibility of pancreatic glucagon secretion was increasingly impaired with decreasing glucose tolerance, and gut hormone levels were normal. In conclusion, at cystic fibrosis (a) insulin secretion is impaired even when glucose tolerance and insulin sensitivity are within the normal range, (b) the glucagon test gives valid estimates of residual beta cell function, (c) pancreatic polypeptide response to oral glucose is absent, (d) glucagon suppressibility decreases with decreasing glucose tolerance, and (e) the enteroinsular axis is intact. |
| تدمد: | 0001-5598 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43cde2499aecf9b5234d31952722833Test https://pubmed.ncbi.nlm.nih.gov/8480468Test |
| رقم الانضمام: | edsair.doi.dedup.....b43cde2499aecf9b5234d31952722833 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00015598 |
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