Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis
| العنوان: | Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis |
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| المؤلفون: | Naoko Nakanishi, Hyou Kim, Mika Kurihara, Mitsuru Sanada, Taishi Nagao, Isamu Yamakawa, Akihiro Kitamura, Ryutaro Nakamura, Shigeki Bamba, Shoko Yasuhara, Masaya Sasaki, Akihiko Itoh, Nobuhiro Ogawa, Makoto Urushitani |
| المصدر: | Annals of Nutrition and Metabolism. 77:236-243 |
| بيانات النشر: | S. Karger AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Spirometry, Sarcopenia, medicine.medical_specialty, Medicine (miscellaneous), Indirect calorimetry, Body composition, Gastroenterology, FEV1/FVC ratio, Internal medicine, medicine, Humans, Resting energy expenditure, Amyotrophic lateral sclerosis, Muscle, Skeletal, Aged, Retrospective Studies, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, Amyotrophic Lateral Sclerosis, Calorimetry, Indirect, Middle Aged, Prognosis, medicine.disease, Basal metabolic rate, Hypermetabolism, Female, Basal Metabolism, Energy Metabolism, business, Bioelectrical impedance analysis |
| الوصف: | Background/aims:Nutritional status is a factor affecting prognosis in patients with amyotrophic lateral sclerosis (ALS). Here, we aimed to clarify the factors associated with hypermetabolism and the prognosticators of ALS. Methods:Forty-two inpatients (22 men, 20 women) diagnosed with ALS according to the revised El-Escorial criteria were investigated. The following data were retrospectively analyzed: anthropometric measurements, blood biochemistry, disease severity, basal energy expenditure (BEE), resting energy expenditure (REE) measured by indirect calorimetry, spirometry, and bioelectrical impedance analysis. Single and multiple regression analysis was performed to examine factors affecting REE and metabolic changes (defined as the ratio of REE to fat-free mass [FFM]). The Kaplan-Meier method was used to examine factors associated with the occurrence of cumulative events (death or tracheostomy). Results:Among the 42 inpatients, REE was significantly higher than BEE, indicating hypermetabolism in ALS. Multiple regression analysis revealed that REE/FFM is strongly associated with the skeletal muscle index (-3.746 to -1.532, p < 0.0001) and percent forced vital capacity (%FVC) (-0.172 to -0.021, p = 0.013). Moreover, both the skeletal muscle index and %FVC were significant prognosticators associated with the occurrence of cumulative events. Conclusions:Energy metabolism was elevated in ALS, and respiratory status and muscle mass were associated with the hypermetabolism and poor prognosis. Adequate nutritional support may improve outcomes in ALS by preventing deterioration of respiratory status and reduction in muscle mass. |
| تدمد: | 1421-9697 0250-6807 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b416d17f08a578c512cb2bab376b9abdTest https://doi.org/10.1159/000518908Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b416d17f08a578c512cb2bab376b9abd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219697 02506807 |
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