A Comparison of HLA-Identical Sibling Allogeneic versus Autologous Transplantation for Diffuse Large B Cell Lymphoma: A Report from the CIBMTR
| العنوان: | A Comparison of HLA-Identical Sibling Allogeneic versus Autologous Transplantation for Diffuse Large B Cell Lymphoma: A Report from the CIBMTR |
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| المؤلفون: | David I. Marks, Jeanette Carreras, Jane N. Winter, Robert Peter Gale, Santiago Pavlovsky, Shimon Slavin, Thomas C. Shea, Koen van Besien, Julie M. Vose, Asli Selmin Ataergin, Richard T. Maziarz, Thomas R. Klumpp, Brandon Hayes-Lattin, Mei-Jie Zhang, Parameswaran Hari, David J. Inwards, Steven C. Goldstein, Gregory A. Hale, Jacob D. Bitran, Philip L. McCarthy, Harry C. Schouten, Cesar O. Freytes, J. Douglas Rizzo, Brian J. Bolwell, Hillard M. Lazarus |
| المساهمون: | Interne Geneeskunde, RS: GROW - School for Oncology and Reproduction |
| المصدر: | Biology of Blood and Marrow Transplantation, 16(1), 35-45. Elsevier Science |
| بيانات النشر: | Elsevier Science, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Oncology, medicine.medical_treatment, Statistics as Topic, Hematopoietic stem cell transplantation, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Medicine, Registries, Histocompatibility Testing, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, Tissue Donors, 3. Good health, Treatment Outcome, surgical procedures, operative, 030220 oncology & carcinogenesis, Disease Progression, Female, Lymphoma, Large B-Cell, Diffuse, Adult, medicine.medical_specialty, Allogeneic transplantation, Adolescent, Unrelated, Lower risk, Transplantation, Autologous, Article, Young Adult, 03 medical and health sciences, Internal medicine, Humans, Transplantation, Homologous, Autologous transplantation, Retrospective Studies, Transplantation, business.industry, Siblings, Retrospective cohort study, medicine.disease, Lymphoma, Surgery, business, Diffuse large B-cell lymphoma, Hodgkin lymphoma, Follow-Up Studies, 030215 immunology |
| الوصف: | We compared outcomes of 916 diffuse large B cell lymphoma (DLBCL) patients aged >or=18 years undergoing first autologous (n = 837) or myeloablative (MA) allogeneic hematopoietic cell transplant (HCT) (n = 79) between 1995 and 2003 reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). Median follow-up was 81 months for allogeneic HCT versus 60 months for autologous HCT. Allogeneic HCT recipients were more likely to have high-risk disease features including higher stage, more prior chemotherapy regimens, and resistant disease. Allogeneic HCT was associated with a higher 1 year treatment-related mortality (TRM) (relative risk [RR] 4.88, 95% confidence interval [CI], 3.21-7.40, P 50 years), lower performance score, chemoresistance, and earlier year of transplant. In a cohort of mainly high-risk DLBCL patients, upfront MA allogeneic HCT, although associated with increased early mortality, was associated with a similar risk of disease progression compared to lower risk patients receiving autologous HCT. American Society for Blood and Marrow Transplantation. All rights reserved. |
| اللغة: | English |
| تدمد: | 1523-6536 1083-8791 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b72493c4132de39b9fae31b45755b5Test https://cris.maastrichtuniversity.nl/en/publications/6abd61d6-c49f-44f8-b042-4202d8048fa9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b3b72493c4132de39b9fae31b45755b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15236536 10838791 |
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