Metabolic effect of islet B-cell function in insulin-treated diabetes
| العنوان: | Metabolic effect of islet B-cell function in insulin-treated diabetes |
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| المؤلفون: | H J Gjessing, Iversen S, Lars Erik Matzen, Ole K. Faber, A. Frøland |
| المصدر: | Gjessing, H J, Matzen, L E, Iversen, S, Faber, O K & Frøland, A 1989, ' Metabolic effect of islet B-cell function in insulin-treated diabetes ', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 49, no. 4, pp. 337-43 . |
| بيانات النشر: | Informa UK Limited, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, medicine.medical_treatment, Clinical Biochemistry, Stimulation, Ketone Bodies, Fatty Acids, Nonesterified, Biology, Glucagon, Islets of Langerhans, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, Insulin Secretion, medicine, Humans, Insulin, Aged, Glycated Hemoglobin, Hemoglobin A, Glycosylated, geography, geography.geographical_feature_category, C-Peptide, C-peptide, Fasting, General Medicine, Middle Aged, Islet, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Metabolic control analysis, Ketone bodies, Female |
| الوصف: | Udgivelsesdato: 1989-Jun We studied the relationship between endogenous insulin secretion and fasting levels of plasma free fatty acids (FFA), plasma acetoacetate plus plasma 3-hydroxybutyrate (total ketone bodies), blood glucose, and HbA1 in 132 diabetic outpatients treated with conventional insulin regimens. Patients were divided into four groups according to plasma C-peptide concentration after intravenous stimulation with glucagon: one group with C-peptide stimulation less than 0.06 nmol/l, one group with C-peptide stimulation 0.06- less than 0.32 nmol/l, one group with C-peptide stimulation 0.32- less than 0.60 nmol/l, and one group with C-peptide stimulation greater than 0.60 nmol/l. According to clinical criteria the prevalence of insulin-dependent diabetes mellitus was approximately 90% in patients with C-peptide stimulation less than 0.32 nmol/l, approximately 25% in patients with C-peptide stimulation from 0.32- less than 0.60 nmol/l, and approximately 10% in patients with C-peptide stimulation greater than 0.60 nmol/l. All metabolic variables were significantly higher in patients without detectable C-peptide in plasma when compared to values found in patients with C-peptide stimulation from 0.06- less than 0.32 nmol/l. These two patient groups also had similar peripheral plasma free insulin levels and were comparable according to age, sex, and body mass index.(ABSTRACT TRUNCATED AT 250 WORDS) |
| تدمد: | 1502-7686 0036-5513 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31bb6ec29022279817f6c163b3a85c7Test https://doi.org/10.3109/00365518909089106Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....b31bb6ec29022279817f6c163b3a85c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15027686 00365513 |
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