Unraveling Axon Guidance during Axotomy and Regeneration
| العنوان: | Unraveling Axon Guidance during Axotomy and Regeneration |
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| المؤلفون: | Miguel E. Domínguez-Romero, Paula G. Slater |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 8344, p 8344 (2021) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Nervous system, QH301-705.5, medicine.medical_treatment, Growth Cones, Central nervous system, Review, Biology, Catalysis, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, guidance cues, Biology (General), Physical and Theoretical Chemistry, Growth cone, QD1-999, Molecular Biology, Spectroscopy, Regeneration (biology), Organic Chemistry, axon regeneration, General Medicine, Axons, spinal cord injury, Axon Guidance, Nerve Regeneration, Computer Science Applications, growth cone, axotomy, Chemistry, Crosstalk (biology), 030104 developmental biology, medicine.anatomical_structure, Peripheral nervous system, Axon guidance, Axotomy, Neuroscience, 030217 neurology & neurosurgery, Signal Transduction |
| الوصف: | During neuronal development and regeneration axons extend a cytoskeletal-rich structure known as the growth cone, which detects and integrates signals to reach its final destination. The guidance cues “signals” bind their receptors, activating signaling cascades that result in the regulation of the growth cone cytoskeleton, defining growth cone advance, pausing, turning, or collapse. Even though much is known about guidance cues and their isolated mechanisms during nervous system development, there is still a gap in the understanding of the crosstalk between them, and about what happens after nervous system injuries. After neuronal injuries in mammals, only axons in the peripheral nervous system are able to regenerate, while the ones from the central nervous system fail to do so. Therefore, untangling the guidance cues mechanisms, as well as their behavior and characterization after axotomy and regeneration, are of special interest for understanding and treating neuronal injuries. In this review, we present findings on growth cone guidance and canonical guidance cues mechanisms, followed by a description and comparison of growth cone pathfinding mechanisms after axotomy, in regenerative and non-regenerative animal models. |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27b1ec1e18b79bf6c4e4824e3977867Test https://doi.org/10.3390/ijms22158344Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b27b1ec1e18b79bf6c4e4824e3977867 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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