Titratable fixed‐ratio combination of basal insulin plus a glucagon‐like peptide‐1 receptor agonist: A novel, simplified alternative to premix insulin for type 2 diabetes
| العنوان: | Titratable fixed‐ratio combination of basal insulin plus a glucagon‐like peptide‐1 receptor agonist: A novel, simplified alternative to premix insulin for type 2 diabetes |
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| المؤلفون: | Julio Rosenstock, Ebaa Al‐Ozairi, Xiaoying Li, Edward B. Jude, Fernando Gomez-Peralta |
| المصدر: | Diabetes, Obesity & Metabolism |
| بيانات النشر: | Blackwell Publishing Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Agonist, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulins, 030209 endocrinology & metabolism, Type 2 diabetes, Review Article, 030204 cardiovascular system & hematology, Lower risk, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, GLP‐1 analogue, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, basal insulin, Review Articles, Glucagon-like peptide 1 receptor, Glycated Hemoglobin, business.industry, Basal insulin, medicine.disease, glycaemic control, Diabetes Mellitus, Type 2, insulin therapy, type 2 diabetes, medicine.symptom, Fixed ratio, business, Weight gain |
| الوصف: | Despite novel therapeutic options, many people with type 2 diabetes (T2D) do not achieve their HbA1c targets. Given the progressive nature of T2D, many individuals not controlled with oral therapy will require advancement to injectable therapy using either a glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA), recently recommended as a first option, or traditionally a basal insulin. However, premix insulins remain frequently used, either as initial injectable therapy or as intensification from basal insulin. Premix insulin injections can potentially provide significant glycaemic improvements to basal insulin but at the expense of increased hypoglycaemia and weight gain and the need for multiple daily doses, which may affect treatment adherence. Real‐world evidence suggests that glycaemic control often remains suboptimal with premix insulins. Fixed‐ratio combinations (FRCs) of basal insulin and GLP‐1 RAs provide a novel alternative to premix insulin for therapy intensification. While no direct comparisons between premix insulins and FRCs are available, results from meta‐analyses suggest that FRCs may offer better HbA1c reductions, a lower risk of hypoglycaemia and less weight gain compared with premix insulin in a simplified treatment regimen. A head‐to‐head trial of T2D treatment intensification with premix insulin and a FRC of basal insulin plus a GLP‐1 RA is currently in progress, which should help to clarify the outcomes for each treatment option. This review discusses the unmet needs of people with T2D treated with premix insulin and provides evidence supporting FRCs of basal insulin and GLP‐1 RAs as an alternative treatment option. |
| اللغة: | English |
| تدمد: | 1463-1326 1462-8902 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27776b7ce8a86c52613046a313d0f32Test http://europepmc.org/articles/PMC8252507Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b27776b7ce8a86c52613046a313d0f32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14631326 14628902 |
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