Improving long-term outcomes in pediatric torcular dural sinus malformations with embolization and anticoagulation: a retrospective review of The Hospital for Sick Children experience
| العنوان: | Improving long-term outcomes in pediatric torcular dural sinus malformations with embolization and anticoagulation: a retrospective review of The Hospital for Sick Children experience |
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| المؤلفون: | Prakash Muthusami, Jerry C. Ku, Hidy Girgis, Peter B. Dirks, Karel G. terBrugge, Timo Krings, Brian W. Hanak, James T. Rutka, Karl Narvacan |
| المصدر: | Journal of Neurosurgery: Pediatrics. 28:469-475 |
| بيانات النشر: | Journal of Neurosurgery Publishing Group (JNSPG), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Pediatrics, medicine.medical_specialty, Databases, Factual, medicine.medical_treatment, Mothers, Conservative Treatment, Nervous System Malformations, Cohort Studies, Dural sinus, Pregnancy, Prenatal Diagnosis, Humans, Medicine, Embolization, Medical diagnosis, Child, Retrospective Studies, Heart Failure, Retrospective review, business.industry, Infant, Newborn, Anticoagulants, Infant, General Medicine, Embolization, Therapeutic, Magnetic Resonance Imaging, Sick child, Natural history, Treatment Outcome, Child, Preschool, Radiological weapon, Cohort, Female, Dura Mater, business, Follow-Up Studies |
| الوصف: | OBJECTIVE Torcular dural sinus malformations (tDSMs) are rare pediatric cerebrovascular malformations characterized by giant venous lakes localized to the midline confluence of sinuses. Historical clinical outcomes of patients with these lesions were poor, though better prognoses have been reported in the more recent literature. Long-term outcomes in children with tDSMs are uncertain and require further characterization. The goal of this study was to review a cohort of tDSM patients with an emphasis on long-term outcomes and to describe the treatment strategy. METHODS This study is a single-center retrospective review of a prospectively maintained data bank including patients referred to and cared for at The Hospital for Sick Children for tDSM from January 1996 to March 2019. Each patient’s clinical, radiological, and demographic information, as well as their mother’s demographic information, was collected for review. RESULTS Ten patients with tDSM, with a mean follow-up of 58 months, were included in the study. Diagnoses were made antenatally in 8 patients, and among those cases, 4 families opted for either elective termination (n = 1) or no further care following delivery (n = 3). Of the 6 patients treated, 5 had a favorable long-term neurological outcome, and follow-up imaging demonstrated a decrease or stability in the size of the tDSM over time. Staged embolization was performed in 3 patients, and anticoagulation was utilized in 5 treated patients. CONCLUSIONS The authors add to a growing body of literature indicating that clinical outcomes in tDSM may not be as poor as initially perceived. Greater awareness of the lesion’s natural history and pathophysiology, advancing endovascular techniques, and individualized anticoagulation regimens may lead to continued improvement in outcomes. |
| تدمد: | 1933-0715 1933-0707 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2652c7623de21f7e5aa436c18f86568Test https://doi.org/10.3171/2021.3.peds20921Test |
| رقم الانضمام: | edsair.doi.dedup.....b2652c7623de21f7e5aa436c18f86568 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19330715 19330707 |
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