Reduced foveal cone density in early idiopathic macular telangiectasia
| العنوان: | Reduced foveal cone density in early idiopathic macular telangiectasia |
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| المؤلفون: | Ethan A. Rossi, David R. Williams, Hongxin Song |
| المصدر: | BMJ Open Ophthalmology, Vol 6, Iss 1 (2021) BMJ Open Ophthalmology |
| بيانات النشر: | BMJ Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, retina, medicine.medical_specialty, Visual acuity, genetic structures, Foveola, Ophthalmoscopy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Foveal, Ophthalmology, medicine, macula, Macular telangiectasia, Retina, medicine.diagnostic_test, business.industry, imaging, Dystrophy, Retinal, RE1-994, medicine.disease, eye diseases, 030104 developmental biology, medicine.anatomical_structure, dystrophy, chemistry, 030221 ophthalmology & optometry, sense organs, medicine.symptom, business |
| الوصف: | ObjectiveIdiopathic macular telangiectasia (MacTel) is considered primarily a vascular disease affecting juxtafoveal retinal capillaries. However, recent evidence suggests that neuronal changes may occur early in disease development. We used high-resolution adaptive optics retinal imaging to elucidate the foveal cone photoreceptor changes at a cellular level in patients with MacTel.Methods and analysisWe used adaptive optics scanning light ophthalmoscopy (AOSLO) to evaluate the foveal cone photoreceptors in the less-affected eye of patients with asymmetric MacTel. AOSLO images of cone photoreceptors were obtained in a 4°×4° area centred on the foveola. Individual cone positions were identified within a 2°×2° area centred on the fovea, using semiautomatic cone marking software with manual correction, permitting calculation of a map of cone density.ResultsIn all participants, one eye was affected with MacTel, the fellow eye was clinically normal or near normal, with visual acuity of 20/25 or better and subtle angiographic leakage. The foveal cone mosaics were continuous with tight packing and cones exhibited normal reflectivity. However, cone density was significantly lower for all participants (mean=80 733 cones/mm2) within 0.5° than the cone density previously reported for normal eyes.ConclusionsFoveal cone density is lower than normal in the clinically less-affected eyes of patients with asymmetric MacTel. This suggests that cone photoreceptor loss may precede classic obvious vascular changes in idiopathic MacTel. |
| اللغة: | English |
| تدمد: | 2397-3269 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22d45c799fe52c627d57ce199e814faTest https://bmjophth.bmj.com/content/6/1/e000603.fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b22d45c799fe52c627d57ce199e814fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23973269 |
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