Serum Zinc, Selenium and Total Antioxidant Contents of Nigerian Children with Asthma: Association with Disease Severity and Symptoms Control
| العنوان: | Serum Zinc, Selenium and Total Antioxidant Contents of Nigerian Children with Asthma: Association with Disease Severity and Symptoms Control |
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| المؤلفون: | Olufemi Samuel Smith, Bankole Peter Kuti, Demilade Kehinde Kuti |
| المصدر: | Journal of Tropical Pediatrics. 66:395-402 |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Antioxidant, Adolescent, medicine.medical_treatment, Nigeria, Nutritional Status, chemistry.chemical_element, medicine.disease_cause, Severity of Illness Index, Gastroenterology, Antioxidants, Selenium, 03 medical and health sciences, 0302 clinical medicine, Disease severity, Interquartile range, 030225 pediatrics, Internal medicine, Severity of illness, medicine, Humans, Micronutrients, 030212 general & internal medicine, Child, Asthma, business.industry, Micronutrient, medicine.disease, Oxidative Stress, Zinc, Cross-Sectional Studies, Infectious Diseases, chemistry, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business, Biomarkers, Oxidative stress |
| الوصف: | BackgroundMicronutrients and antioxidants may ameliorate oxidative stress. This study aimed to determine the serum Zinc (Zn), Selenium (Se) and Total Antioxidant Contents (TAC) of Nigerian children with asthma and relate these to disease severity and symptoms controlMethodsChildren aged 2–15 years with asthma and age and sex matched controls were consecutively recruited. The children’s serum Zn, Se and TAC were assayed and compared.ResultsEighty children each with asthma and controls participated in the study. Serum Zn (71.0 ± 30.3 µg/dl vs. 84.2 ± 31.7 µg/dl; p = 0.008), Se (67.3 ± 29.8 µg/l vs. 80.0 ± 31.7 µg/l; p = 0.033) and TAC [median (interquartile range) 5.2 (3.8–6.8) ng/dl vs. 6.2 (4.3–8.0) ng/dl; p = 0.019] were lower in children with asthma. Serum Se (65.7 ± 29.1 µg/l vs. 92.4 ± 28.6 µg/l; p = 0.001) was lower in those with moderate/severe than mild disease, but no association with symptoms control (p > 0.05).ConclusionMicronutrient supplementation may be beneficial in Nigerian children with asthma as they have relatively lower antioxidant micronutrients than nonasthmatics |
| تدمد: | 1465-3664 0142-6338 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20cc117b824fc77bac07b9598665a96Test https://doi.org/10.1093/tropej/fmz078Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b20cc117b824fc77bac07b9598665a96 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14653664 01426338 |
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