Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects
| العنوان: | Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects |
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| المؤلفون: | Roberto Furlan, Ezio Bonifacio, Diego Franciotta, G. Comi, S. Zanaboni, Gianvito Martino, Raffaella Fazio, Vito Lampasona |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, Encephalomyelitis, Autoimmune, Experimental, Adolescent, Encephalomyelitis, Autoantigens, Myelin oligodendrocyte glycoprotein, Mice, Radioligand Assay, Multiple Sclerosis, Relapsing-Remitting, immune system diseases, Animals, Humans, Medicine, Autoantibodies, biology, business.industry, Multiple sclerosis, Middle Aged, Multiple Sclerosis, Chronic Progressive, medicine.disease, Oligodendrocyte, nervous system diseases, Mice, Inbred C57BL, Myelin-Associated Glycoprotein, Titer, medicine.anatomical_structure, Immunoglobulin M, nervous system, Immunoglobulin G, Immunology, biology.protein, Female, Myelin-Oligodendrocyte Glycoprotein, Rabbits, Subacute Sclerosing Panencephalitis, Neurology (clinical), Radiobinding assay, Antibody, business, Myelin Proteins, Demyelinating Diseases |
| الوصف: | The authors used a liquid-phase radiobinding assay to measure serum anti-myelin oligodendrocyte protein (MOG) immunoglobulin (Ig) G in 87 patients with multiple sclerosis (MS), in 12 patients with encephalomyelitis, and in 47 healthy subjects. Anti-MOG IgM was determined in samples obtained at onset from 40 of 87 patients with MS and in control subjects. The frequency of positive samples with low titers of anti-MOG IgG (or =5.7%) and IgM (or =8.3%) was similar in all the groups and subgroups. Binding competition experiments showed that these antibodies had low affinity. Anti-MOG antibodies are not disease specific. |
| تدمد: | 1526-632X 0028-3878 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ff520d4da016b9b96d7d009059ac6dTest https://doi.org/10.1212/01.wnl.0000127615.15768.aeTest |
| رقم الانضمام: | edsair.doi.dedup.....b1ff520d4da016b9b96d7d009059ac6d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X 00283878 |
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