Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
| العنوان: | Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population |
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| المؤلفون: | José Jaime Martínez-Magaña, Sandra Hernandez, Ana Rosa Garcia, Valeria Cardoso-Barajas, Emmanuel Sarmiento, Beatriz Camarena, Alejandro Caballero, Laura Gonzalez, Jorge Ameth Villatoro-Velazquez, Maria Elena Medina-Mora, Marycarmen Bustos-Gamiño, Clara Fleiz-Bautista, Carlos Alfonso Tovilla-Zarate, Isela Esther Juárez-Rojop, Humberto Nicolini, Alma Delia Genis-Mendoza |
| المصدر: | Nutrients Nutrients; Volume 14; Issue 2; Pages: 394 Nutrients, Vol 14, Iss 394, p 394 (2022) |
| بيانات النشر: | MDPI, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Male, Nutrition and Dietetics, genome-wide association study, Adolescent, Nutrition. Foods and food supply, methylation quantitative trait loci, Quantitative Trait Loci, DNA, Feeding Behavior, DNA Methylation, Mendelian Randomization Analysis, feeding and eating disorder, Polymorphism, Single Nucleotide, Article, Feeding and Eating Disorders, Young Adult, Humans, TX341-641, Computer Simulation, Female, Genetic Predisposition to Disease, Mexico, Food Science |
| الوصف: | Alterations in eating behavior characterized eating disorders (ED). The genetic factors shared between ED diagnoses have been underexplored. The present study performed a genome-wide association study in individuals with disordered eating behaviors in the Mexican population, blood methylation quantitative trait loci (blood-meQTL), summary data-based Mendelian randomization (SMR) analysis, and in silico function prediction by different algorithms. The analysis included a total of 1803 individuals. We performed a genome-wide association study and blood-meQTL analysis by logistic and linear regression. In addition, we analyzed in silico functional variant prediction, phenome-wide, and multi-tissue expression quantitative trait loci. The genome-wide association study identified 44 single-nucleotide polymorphisms (SNP) associated at a nominal value and seven blood-meQTL at a genome-wide threshold. The SNPs show enrichment in genome-wide associations of the metabolic and immunologic domains. In the in silico analysis, the SNP rs10419198 (p-value = 4.85 × 10−5) located on an enhancer mark could change the expression of PRR12 in blood, adipocytes, and brain areas that regulate food intake. Additionally, we found an association of DNA methylation levels of SETBP1 (p-value = 6.76 × 10−4) and SEMG1 (p-value = 5.73 × 10−4) by SMR analysis. The present study supports the previous associations of genetic variation in the metabolic domain with ED. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1aee63fc71378bd29e296d538c38ecbTest http://europepmc.org/articles/PMC8778304Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b1aee63fc71378bd29e296d538c38ecb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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