Free water determines diffusion alterations and clinical status in cerebral small vessel disease
| العنوان: | Free water determines diffusion alterations and clinical status in cerebral small vessel disease |
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| المؤلفون: | Martin Dichgans, Rainer Malik, Ebru Baykara, Anil M. Tuladhar, Sofia Finsterwalder, Reinhold Schmidt, Marco Duering, Benno Gesierich, Marek J. Konieczny, Frank-Erik de Leeuw, Michael Ewers, Ofer Pasternak, Eric Jouvent, Nicolai Franzmeier, Geert Jan Biessels |
| المصدر: | Alzheimer's & Dementia, 14, 6, pp. 764-774 Alzheimer's and dementia 14(6), 764-774 (2018). doi:10.1016/j.jalz.2017.12.007 Alzheimer's & Dementia, 14, 764-774 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Pathology, medicine.medical_specialty, Epidemiology, Disease, methods [Diffusion Tensor Imaging], Article, White matter, Leukoencephalopathy, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, Developmental Neuroscience, Alzheimer Disease, Extracellular fluid, Extracellular, medicine, Humans, ddc:610, CADASIL, Aged, business.industry, Health Policy, Water, Middle Aged, medicine.disease, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Hyperintensity, Psychiatry and Mental health, 030104 developmental biology, medicine.anatomical_structure, Diffusion Tensor Imaging, Cerebral Small Vessel Diseases, Female, diagnostic imaging [Cerebral Small Vessel Diseases], Neurology (clinical), Geriatrics and Gerontology, business, diagnostic imaging [Alzheimer Disease], 030217 neurology & neurosurgery, Diffusion MRI |
| الوصف: | Introduction Diffusion tensor imaging detects early tissue alterations in Alzheimer's disease and cerebral small vessel disease (SVD). However, the origin of diffusion alterations in SVD is largely unknown. Methods To gain further insight, we applied free water (FW) imaging to patients with genetically defined SVD (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy [CADASIL], n = 57), sporadic SVD (n = 444), and healthy controls (n = 28). We modeled freely diffusing water in the extracellular space (FW) and measures reflecting fiber structure (tissue compartment). We tested associations between these measures and clinical status (processing speed and disability). Results Diffusion alterations in SVD were mostly driven by increased FW and less by tissue compartment alterations. Among imaging markers, FW showed the strongest association with clinical status (R 2 up to 34%, P Discussion Diffusion alterations and clinical status in SVD are largely determined by extracellular fluid increase rather than alterations of white matter fiber organization. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1552-5260 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b162f623377345c4736c9f9ca1f4c8cdTest https://europepmc.org/articles/PMC5994358Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b162f623377345c4736c9f9ca1f4c8cd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15525260 |
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