MicroRNA‐375‐3p inhibitor suppresses angiotensin II‐induced cardiomyocyte hypertrophy by promoting lactate dehydrogenase B expression
| العنوان: | MicroRNA‐375‐3p inhibitor suppresses angiotensin II‐induced cardiomyocyte hypertrophy by promoting lactate dehydrogenase B expression |
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| المؤلفون: | Wei Ouyang, Huijuan Feng, Guoquan Zhu, Pan Chen, Jialang Xian, Liu-hua Huang, Jing Wang, Juqing Wu, Yuying Deng |
| المصدر: | Journal of Cellular Physiology. 234:14198-14209 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Physiology, Lactate dehydrogenase B, Primary Cell Culture, Clinical Biochemistry, Cardiomegaly, Peptide, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Internal medicine, Natriuretic Peptide, Brain, microRNA, medicine, Animals, Humans, Myocytes, Cardiac, Aorta, Heart Failure, chemistry.chemical_classification, Gene knockdown, Messenger RNA, L-Lactate Dehydrogenase, Myosin Heavy Chains, Chemistry, Angiotensin II, Myocardium, Cell Biology, medicine.disease, Rats, Isoenzymes, Disease Models, Animal, MicroRNAs, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Heart failure, cardiovascular system, Signal Transduction |
| الوصف: | Cardiac hypertrophy is a myocardial enlargement due to overload pressure, and the primary cause of heart failure. We investigated the function of miR-375-3p in cardiac hypertrophy and its regulating mechanisms. miR-375-3p was upregulated in hearts of the transverse aortic constriction rat model and angiotensin II (Ang II)-induced primary cardiomyocyte hypertrophy model; the opposite was observed for lactate dehydrogenase B (LDHB) protein expression. miR-375-3p knockdown reduced the surface area of primary cardiomyocytes increased by Ang II treatment and decreased the B-natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC) messenger RNA (mRNA) and protein levels. miR-375-3p was also observed to directly target LDHB. LDHB knockdown increased the surface area of Ang II-treated primary cardiomyocytes and increased the BNP and β-MHC mRNA and protein levels. LDHB knockdown attenuated the effects of miR-375-3p on the surface area of primary cardiomyocytes and BNP and β-MHC levels. Therefore, miR-375-3p inhibitor suppresses Ang II-induced cardiomyocyte hypertrophy by promoting LDHB expression. |
| تدمد: | 1097-4652 0021-9541 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b161e9452c144953773c7dd98b73dbc8Test https://doi.org/10.1002/jcp.28116Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b161e9452c144953773c7dd98b73dbc8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974652 00219541 |
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