Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
| العنوان: | Insulin Resistance Alters Islet Morphology in Nondiabetic Humans |
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| المؤلفون: | Rohit N. Kulkarni, Alfredo Pontecorvi, Gian Pio Sorice, Andrea Giaccari, Gennaro Clemente, Jens J. Holst, Giovanna Muscogiuri, Jiang Hu, Teresa Mezza |
| المساهمون: | Mezza, T., Muscogiuri, G., Sorice, G. P., Clemente, G., Hu, J., Pontecorvi, A., Holst, J. J., Giaccari, A., Kulkarni, R. N. |
| المصدر: | Diabetes |
| بيانات النشر: | American Diabetes Association, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, insulin secretion, transdifferentiation, transdifferenziazione, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Glucose uptake, secrezione insulinica, Type 2 diabetes, neogenesi, Glucagon-Like Peptide 1, Insulin-Secreting Cells, geography.geographical_feature_category, isole pancreatiche, Middle Aged, Islet, Insulin oscillation, medicine.anatomical_structure, insulino resistenza, Female, Glucagon-Secreting Cell, neogenesis, Human, Adult, medicine.medical_specialty, Incretin, Biology, Islets of Langerhans, Pancreatectomy, Insulin resistance, beta cellule, Internal medicine, Internal Medicine, medicine, Humans, Aged, geography, Hyperplasia, pancreatic islets, Insulin, Pancreatic islets, Islets of Langerhan, Settore MED/13 - ENDOCRINOLOGIA, medicine.disease, beta cells, Endocrinology, Islet Studies, Glucagon-Secreting Cells, Insulin-Secreting Cell, Insulin Resistance |
| الوصف: | Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insulin secretion fails to cope with worsening insulin resistance. In addition to its effects on skeletal muscle, liver, and adipose tissue metabolism, it is evident that insulin resistance also affects pancreatic β-Cells. To directly examine the alterations that occur in islet morphology as part of an adaptive mechanism to insulin resistance, we evaluated pancreas samples obtained during pancreatoduodenectomy from nondiabetic subjects who were insulin-resistant or insulin-sensitive. We also compared insulin sensitivity, insulin secretion, and incretin levels between the two groups. We report an increased islet size and an elevated number of band a-cells that resulted in an altered β-Cell-to-a-cell area in the insulin- resistant group. Our data in this series of studies suggest that neogenesis from duct cells and transdifferentiation of a-cells are potential contributors to the β-Cell compensatory response to insulin resistance in the absence of overt diabetes. © 2014 by the American Diabetes Association.. |
| اللغة: | English |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1145e717731d2908b39e2d0b6181cbeTest http://europepmc.org/articles/PMC3931397Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b1145e717731d2908b39e2d0b6181cbe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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