Effect of the natural sweetener xylitol on gut hormone secretion and gastric emptying in humans:A pilot dose-ranging study
| العنوان: | Effect of the natural sweetener xylitol on gut hormone secretion and gastric emptying in humans:A pilot dose-ranging study |
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| المؤلفون: | Carel W. le Roux, Anne Christin Meyer-Gerspach, Christoph Beglinger, Ralph Peterli, Jürgen Drewe, Jens F. Rehfeld, Jan Tack, Ludmilla Dellatorre-Teixeira, Wout Verbeure, Bettina K. Wölnerhanssen, Jens J. Holst, Bolette Hartmann |
| المصدر: | Meyer-Gerspach, A C, Drewe, J, Verbeure, W, Le Roux, C W, Dellatorre-Teixeira, L, Rehfeld, J F, Holst, J J, Hartmann, B, Tack, J, Peterli, R, Beglinger, C & Wölnerhanssen, B K 2021, ' Effect of the natural sweetener xylitol on gut hormone secretion and gastric emptying in humans : A pilot dose-ranging study ', Nutrients, vol. 13, no. 1, 174 . https://doi.org/10.3390/nu13010174Test Nutrients Volume 13 Issue 1 Nutrients, Vol 13, Iss 174, p 174 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Glucose, Male, gut hormones, medicine.medical_treatment, Blood lipids, Gastric emptying, Xylitol, chemistry.chemical_compound, Glucagon-Like Peptide 1, Insulin, Cholecystokinin, Cross-Over Studies, Nutrition and Dietetics, digestive, oral, and skin physiology, Dipeptides, Lipids, appetite-related sensations, Female, lcsh:Nutrition. Foods and food supply, Adult, medicine.medical_specialty, lcsh:TX341-641, Gastric Inhibitory Polypeptide, natural sweeteners, Glucagon, Article, Gastrointestinal symptoms, Motilin, Gastrointestinal Hormones, Young Adult, gastric emptying, Double-Blind Method, uric acid, Internal medicine, medicine, Humans, blood lipids, Natural sweeteners, Gut hormones, Endocrinology, chemistry, gastrointestinal symptoms, Sweetening Agents, Appetite-related sensations, Uric acid, Food Science, Hormone |
| الوصف: | Sugar consumption is associated with a whole range of negative health effects and should be reduced and the natural sweetener xylitol might be helpful in achieving this goal. The present study was conducted as a randomized, placebo-controlled, double-blind, cross-over trial. Twelve healthy, lean volunteers received intragastric solutions with 7, 17 or 35 g xylitol or tap water on four separate days. We examined effects on: gut hormones, glucose, insulin, glucagon, uric acid, lipid profile, as well as gastric emptying rates, appetite-related sensations and gastrointestinal symptoms. We found: (i) a dose-dependent stimulation of cholecystokinin (CCK), active glucagon-like peptide-1 (aGLP-1), peptide tyrosine tyrosine (PYY)-release, and decelerated gastric emptying rates, (ii) a dose-dependent increase in blood glucose and insulin, (iii) no effect on motilin, glucagon, or glucose-dependent insulinotropic peptide (GIP)-release, (iv) no effect on blood lipids, but a rise in uric acid, and (v) increased bowel sounds as only side effects. In conclusion, low doses of xylitol stimulate the secretion of gut hormones and induce a deceleration in gastric emptying rates. There is no effect on blood lipids and only little effect on plasma glucose and insulin. This combination of properties (low-glycemic sweetener which stimulates satiation hormone release) makes xylitol an attractive candidate for sugar replacement. ispartof: NUTRIENTS vol:13 issue:1 ispartof: location:Switzerland status: published |
| وصف الملف: | application/pdf; Electronic |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1107dc223b627169f8a89a55c8fc709Test https://curis.ku.dk/ws/files/256896617/nutrients_13_00174_v2.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b1107dc223b627169f8a89a55c8fc709 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |