Fetal alcohol spectrum disorders: Genetic and epigenetic mechanisms
| العنوان: | Fetal alcohol spectrum disorders: Genetic and epigenetic mechanisms |
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| المؤلفون: | Nina Kaminen-Ahola |
| المصدر: | Prenatal Diagnosis. 40:1185-1192 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Alcohol Drinking, Maternal smoking, 030105 genetics & heredity, Bioinformatics, Epigenesis, Genetic, 03 medical and health sciences, Fetal alcohol, 0302 clinical medicine, Pregnancy, Humans, Medicine, Epigenetics, Allele, reproductive and urinary physiology, Genetics (clinical), 030219 obstetrics & reproductive medicine, Ethanol, business.industry, Gene Expression Regulation, Developmental, Obstetrics and Gynecology, Phenotype, 3. Good health, Review article, Pregnancy Complications, Fetal Alcohol Spectrum Disorders, Prenatal Exposure Delayed Effects, Prenatal alcohol exposure, Etiology, Female, business |
| الوصف: | Fetal alcohol spectrum disorders (FASD) are a consequence of prenatal alcohol exposure (PAE). The etiology of the complex FASD phenotype with growth deficit, birth defects, and neurodevelopmental impairments is under extensive research. Both genetic and environmental factors contribute to the wide phenotype: chromosomal rearrangements, risk and protective alleles, environmental-induced epigenetic alterations as well as gene-environment interactions are all involved. Understanding the molecular mechanisms of PAE can provide tools for prevention or intervention of the alcohol-induced developmental disorders in the future. By revealing the alcohol-induced genetic and epigenetic alterations which associate with the variable FASD phenotypes, it is possible to identify biomarkers for the disorder. This would enable early diagnoses and personalized support for development of the affected child. |
| تدمد: | 1097-0223 0197-3851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ba31d1101b765414f847746be82b44Test https://doi.org/10.1002/pd.5731Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b0ba31d1101b765414f847746be82b44 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970223 01973851 |
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